Patient: I saw your reply, from which we know that “acute myeloid leukemia with abnormal expression of lytic antigen” cannot be simply interpreted as “acute myeloid leukemia”, because there are poor prognostic factors, and therefore, it is difficult to determine the typing of leukemia. Is this true? In the future, the patient’s main chemotherapy regimen will be a myeloid regimen, is this possible? In addition, the patient is only semi-identical to his father, and because few hospitals in Yunnan have done this, and because of geographic and economic reasons, the patient is not yet eligible for transplantation, and has to rely on chemotherapy for maintenance while waiting for news of a fully compatible match. Reply: The typing is myeloid, but the more specific is myeloid. Hemiphasic transplantation is indeed risky and costly, so you must be careful before proceeding with treatment. If you intend to proceed with transplantation, we suggest that you make sure that you understand the diagnosis and determine if there are any other poor prognostic factors. Patient: You have indicated the condition for us. The patient had a bone aspiration and routine blood tests on November 28, the results of which were: all the main indicators of blood tests were normal (the doctor thought so too), but the bone aspiration showed: 66% prohematocrit. Today (Dec. 1), the bone puncture showed 45% protohematocrit and all the major blood count indicators were normal (the doctor also thought so), but the doctor said that “the patient has relapsed and needs to be hospitalized for chemotherapy”. What is the reason for the abnormal blood count and the abnormal bone scan? What is the relationship between the blood count and the results of the bone aspiration? The bone marrow is a hematopoietic organ. According to the information you provided, the bone marrow has a large number of primitive cells, which is already a full relapse, but it has not yet affected the peripheral blood, if the disease state is not controlled, as time goes by, the disease progresses, sooner or later it will affect the peripheral blood, and then the blood routine will be abnormal, and there will be abnormal feelings. Chemotherapy should be given as soon as possible to achieve a second CR (complete remission), and then a hematopoietic stem cell transplant, regardless of whether the HLA match is full or hemizygous. Patient: The patient has already had 4 days of chemotherapy, and his drug regimen is; fludarabine 4 bottles (50ml each) one bottle a day, asperuloside 100mg a day, and one vincristine on the first day of chemotherapy. Now, the initial look of the disease is basically under control. From tomorrow onwards fludarabine is discontinued and the dosage of acephalosporin is increased to 150 mg per day. What do you think of this plan? The patient basically had no major reaction to the first and second chemotherapy, but this time the reaction is still big, mainly no appetite, low fever for three days, all over the body, today the fever stopped, the rest of the body is fine. We fully accept your advice and will prepare for the transplant as soon as possible. Also, please take a look at the father-son match, is there a pure match? If so, is the success rate higher than the usual hemizygous? Patient: I’ve sent you the matching table of the father and son, please check it and take the time to answer it. Reply: I have replied, please check. Patient: We are taking your advice and making every effort to prepare for the transplant as soon as possible. If the transplant is successful, will the patient be able to live like a normal person? What will be the result if the transplant fails? Reply: Indeed, after a successful transplant, you can live like a normal person, but within a certain time frame, the immunity is still relatively poor and you should pay attention to prevent infection. There are many possibilities of transplant failure: blood picture does not recover, disease does not remit, unstable condition, etc. That depends on which kind of transplant you are doing. Patient: Since the patient has not yet found a fully compatible match, the situation is not good after the seventh chemotherapy, i.e., the routine blood was done on the 10th day after chemotherapy, and the naive cells were 2/50; the manual typing was done on the 15th day at the county hospital, and it was seen that the naive cells were 6%, and the doctor also said that the patient’s situation was not optimistic, and the eighth course of chemotherapy should be carried out. After remission, we could only prepare for a hemiphasic transplant with my father. So, we are preparing for a hemiphasic transplant. Can you tell me what to pay attention to before transplantation? How to prevent it? Reply: As I said before, you should be careful with hemiphasic transplantation. I don’t know what your specific condition is now, so it’s hard to judge. There are many things to pay attention to before transplantation, specifically in two categories: medical staff patients and family members medical staff, I will not say much. There are many preparations for patients and family members, and each transplant center is not quite the same, but there should be a pre-transplant routine rules, there may be many, such as the preparation of clothes, clean diet, attention to hygiene and some other details, in short, if you do not know too much, and not how to read and understand the transplant routine, then you should ask the doctor about everything, you can not make your own decisions, even if it is a change of clothes, what kind of food to eat, etc. If you don’t know anything about transplantation and don’t understand the transplantation routine, you should ask your doctor about everything and not make your own decisions, even if it’s a change of clothes, what kind of food to eat, etc., you should pay high attention to it and never be careless.