The mechanisms by which drugs cause sexual dysfunction are complex, but commonly affect hormone secretion and metabolism. As far as we know, there are more than 40 kinds of drugs that can cause ED. The most common are the following categories: diuretics such as antidiuretics, is a kind of aldosterone antagonist, it can inhibit the activity of testosterone synthase, so that the synthesis of testosterone is reduced, the blood level decreased. It can cause 20% of men to experience a loss of libido. In addition, diuretics can make the body lose potassium, the blood potassium concentration decreases, so that the neuromuscular sensitivity is reduced, the vascular smooth muscle relaxation, which can lead to a weakened penile erection. Antihypertensive drugs This is a common drug that affects male sexual function. 25% of patients taking antihypertensive drugs have ED, while only 7% of healthy people not taking drugs have ED. in addition, 25% of people taking antihypertensive drugs have ejaculatory disorders. Risperdal and colestipol all have an effect on the nervous system, ultimately leading to ED. Sedative Drugs High doses of Valium have a direct specific effect on the limbic system of the brain, directly reducing or enhancing the function of sexual desire. Valium and others have a muscle relaxing effect, which can lead to decreased libido and ED. Hormones Estrogen: commonly used clinically in the treatment of benign prostatic hyperplasia, these patients, there will be breast hyperplasia, reduced and slowed beard growth, decreased libido, decreased erectile function, ejaculation disorders, decreased semen volume and other obvious side effects. Adrenocorticotropic hormones: such as prednisone and dexamethasone, are used to treat immune infertility with antisperm antibodies to suppress the patient’s immune response, but sexual dysfunction can occur when the dosage reaches 20 mg per day. In addition, long-term use of such drugs can induce diabetes, hypertension, obesity and so on. Testosterone: testosterone has been popular as a sex hormone that can “rejuvenate”, but some ED patients who have taken a few injections to see the effect, then blindly abused, and as a result, the condition is aggravated. This is because a large number of foreign testosterone inhibit the endocrine function of the pituitary gland and testes, so that the endogenous testosterone secretion is reduced, especially those psychological impotence patients were not lack of testosterone, after the use of the drug, but interfere with the normal metabolism and endocrine function. Cyproterone: It is a synthetic steroidal compound with anti-androgenic activity, which plays a competitive inhibitory role in androgenic target organs. During the use of the drug can lead to reproductive endocrine axis system disorders, a week or so can be seen in the loss of libido, erectile dysfunction and other symptoms. Antipsychotics Some drugs paralyze the sphincter of the seminal vesicle and decrease ejaculatory capacity, while others can cause a decrease in testosterone levels and impaired spermatogenesis. Antidepressants amitriptyline, doxepin, etc. can make the congestion of the penile corpus cavernosum subside, delayed and postponed, so some people use this treatment for premature ejaculation, but a large number of long-term use, due to the general constriction of the blood vessels will make the penis erection weakness, resulting in ED.