Small details to keep in mind when taking medication for coronary artery disease

Coronary heart disease, also known as ischemic heart disease, is one of the most common cardiovascular diseases in middle-aged and elderly people, known as the human “first killer”. Patients in the drug treatment of coronary heart disease, first, under the guidance of the doctor according to the symptoms of drug selection, and second, pay special attention to some small details, so as not to reduce the efficacy of drugs due to misuse, wrong service, or lose the best chance of salvage. First, can not casually increase the amount of drugs Some patients with coronary heart disease, hate can not be cured at once, not in accordance with the doctor’s instructions to take medication, unauthorized increase in the amount of drugs, the results of the desire for speed is not enough. For example, nitroglycerin is a fast-acting drug to relieve angina, and individuals who do not see the effect of a single dose of nitroglycerin will be able to take several tablets within a short period of time, resulting in not only poor efficacy, but also worsening pain. This is because arbitrarily increasing the amount of nitroglycerin can directly cause spasm of the ductus arteriosus, but also produce drug resistance. Therefore, but because of the poor effect of the drug, due to timely access to the hospital. Second, can not just stop the drug coronary heart disease is the need for long-term adherence to medication, patients with medication can not be arbitrary, otherwise the condition at any time may change or even aggravate. Some patients with coronary heart disease in chest tightness, breathlessness and other symptoms when the drug is very punctual, once the condition has improved, or the symptoms disappear when the drug is discontinued at will. For patients with coronary heart disease, the sudden stopping of medication can be fatal. For example, a long time to take metoprolol coronary heart disease patients can not stop taking the drug, otherwise it will cause “rebound”, exacerbate angina and even myocardial infarction. When to stop the drug, it is best to listen to the doctor’s advice, do not take the initiative. Third, diarrhea, abdominal pain can not self-medication Mild diarrhea does not require special medication, the general symptoms will not exceed 48 hours. Coronary heart disease patients appear diarrhea, abdominal pain, especially pay attention to, sometimes is the heart problem performance of the illusion. Because acute lower wall myocardial infarction is often manifested as epigastric pain, sometimes accompanied by vomiting, diarrhea, often make people think that it is acute gastroenteritis, and only take antidiarrheal drugs will inevitably delay the condition, losing the best chance of rescue. Therefore, coronary heart disease patients once diarrhea, abdominal pain and other conditions, should not take their own antidiarrheal drugs, due to go to the regular hospital. Fourth, can not just take pCms Although the Chinese medicine treatment of coronary heart disease has a unique advantage, but the treatment of coronary heart disease can not be randomly combined with the application of pCms, especially when the ingredients are not clear should be more cautious. 1, should not casually take pCms containing ephedra. Ephedra contains ephedrine, ephedrine’s pharmacological effect is similar to adrenaline, can strengthen myocardial contractility, make blood vessel contraction, heart rate increase, thus increasing the burden on the heart, can induce angina pectoris. Anti-cold and cough and asthma class of proprietary Chinese medicines usually contain ephedra: such as Lianhua Qingdian, half-summer cough syrup, Syrup of Acute Branch, Tongxuan Lung Pills, Qianbai Rhinitis Capsules, Sufi cough syrup, wind and pain pills and so on. 2, should not be taken casually to activate blood circulation and eliminate blood stasis class of proprietary Chinese medicines. Aspirin is one of the most commonly used drugs in patients with coronary heart disease, with anti-platelet aggregation, not only can effectively reduce the risk of stable and unstable angina patients, and can reduce the risk of acute myocardial infarction and stroke. The combination of aspirin with blood-activating and stasis-eliminating Chinese patent medicines containing Salvia divinorum, safflower, and ginkgo containing Salvia divinorum is prone to induce hemorrhagic disorders. Aspirin and deer antler, licorice and preparations for joint use, can increase the aspirin gastrointestinal adverse reactions, easy to cause gastric ulcers, gastric bleeding or gastric perforation. Fifth, can not just take Western medicine Clinically used many Western drugs have heart toxic side effects, coronary heart disease patients should not buy their own take. 1, macrolide antibacterial drugs: such as clarithromycin, arrhythmia, bradycardia, Q-T interval prolongation, ischemic heart disease, congestive heart failure and other patients are prohibited. 2, gastrointestinal dynamics drugs: such as cisapride, heart disease, arrhythmia, QT interval prolongation is prohibited. 3, non-steroidal anti-inflammatory drugs: such as ibuprofen, patients with severe cardiac insufficiency (due to the inhibition of renal prostaglandin biosynthesis, causing edema, increasing the amount of circulating body fluids, increasing the workload of the heart, may worsen the symptoms). 4, anti-migraine drugs: such as rizatriptan, is prohibited in patients with localized ischemic heart disease (eg: angina pectoris, myocardial infarction or documented asymptomatic ischemia). 5.Anti-dementia drugs: such as strychnine A, galantamine, etc., angina and other patients are prohibited. 6.Smoking cessation drugs: such as nicotine patches, unstable or worsening angina pectoris, acute myocardial infarction, severe arrhythmia is prohibited. 7, anti-sickness drugs: such as scopolamine, cardiovascular disease (heart failure, myocardial infarction, conduction abnormalities) and ischemic heart disease patients are prohibited. 8, antihistamines: astemizole and terfenadine are metabolized by P450 enzyme in the body and become active metabolites. When the metabolism of these two drugs is inhibited, such as liver disease or drug inhibition of P450 enzyme system of the 3A family, can cause fatal arrhythmia – tip-twist arrhythmia. Diphenhydramine causes tip-twisting ventricular tachycardia and serious arrhythmias no less dangerous than terfenadine, blocking delayed K+ channels and prolonging the Q-T interval. Therefore, the use of these drugs should be highly emphasized in the elderly, patients with hepatic insufficiency, hypokalemia, and hypomagnesemia.