Marie first described acromegaly in 1886, and in 1887 Minkowski discussed acromegaly caused by abnormal arrangement of pituitary glands. In 1900 Benda recognized eosinophilic adenoma with acromegaly and demonstrated that the tumor was a true tumor from anterior pituitary cells. In 1908, Marburg recognized the clinical manifestation of hypopituitarism in nonsecretory pituitary adenomas. In 1909, Cushing further elucidated and explained the clinical relationship between hypopituitarism caused by secretory eosinophilic adenomas (acromegaly) and hypopituitarism caused by nonsecretory adenomas (suspensory cell tumors). In the following decades, Cushing and his colleagues focused on the pathology, clinical features, and endocrine abnormalities of pituitary tumors, further expanding and enriching the overall knowledge of pituitary tumors. Further refinement of the safety and efficacy of treatment In the last 20 years, clinical and research work on pituitary tumors has developed rapidly, but there are still a number of challenges to continue to conclude research.