When it comes to chemotherapy, many patients are afraid of it. Even many patients may therefore choose to give up chemotherapy and choose some folk remedies, or online, relatives pass each other’s Chinese medicine treatment. Of course, we do not oppose to TCM treatment, but we suggest regular TCM treatment, as Chinese medicine is profound and profound, and it is about discriminative treatment. Of course, when it comes to intestinal cancer, chemotherapy is not as terrible as imagined. However, it is admitted that chemotherapy drugs may harm the body, because the current chemotherapy drugs, besides killing cancer cells, also damage normal cells, such as bone marrow hematopoietic stem cells, digestive tract mucosa and skin, etc. All patients will have corresponding side effects after chemotherapy. The common side effects include gastrointestinal reactions, bone marrow transplantation, hand-foot syndrome, and neurotoxicity. But most patients can tolerate it, and some common diseases can be prevented and treated well through some treatment and conditioning. So don’t worry too much. At present, the treatment of tumor is mainly a comprehensive treatment based on surgery. Surgery removes the tumor that can be seen by the naked eye, which directly removes the largest load of tumor inside the body. However, the cancer cells in the blood and lymphatic system, which cannot be seen by the eyes, need chemotherapy and radiotherapy to eliminate. This can greatly reduce the chance of tumor recurrence and metastasis. Moreover, chemotherapy is not a one-size-fits-all treatment, not every patient needs chemotherapy. Early stage intestinal cancer does not need chemotherapy, but of course we should review it regularly after surgery, because a small percentage of this group of patients will have recurrence and metastasis after surgery. Chemotherapy for stage II patients is still controversial and a hot topic of research at present. Chemotherapy is recommended for patients with high risk factors such as obstruction, perforation, poorly differentiated tumor, T 4, lymph nodes sent for examination less than 12, and vascular nerve invasion. In particular, the 5-year postoperative survival rate for T4, stage IIc patients is even lower than that of stage III patients. Patients with stage II are recommended to have MMR protein test or MSI test. Patients with dMMR or MSI-H have better prognosis and can be treated without chemotherapy. Patients with MSS,MSI-L can be treated with oral capecitabine. For patients with poor physical condition or elderly patients, periodic review is possible. Chemotherapy is strongly recommended for stage III patients. Stage IV patients are generally not recommended for direct surgery unless there is a risk of obstruction, perforation, bleeding, etc., or metastases are considered resectable. Chemotherapy is administered first, and some patients’ tumors can shrink through chemotherapy and reach resectability before surgery. It should be emphasized that some patients with stage IV tumor and advanced tumor patients can still have a better survival rate or even achieve “cure” through chemotherapy and surgery, not that they are hopeless and have no therapeutic value as understood by the old people.