Mastocytosis is a benign hyperplastic lesion of the breast and is generally treated conservatively with medication. However, about 2% to 3% of patients will develop malignant changes, which are closely related to breast cancer. Therefore, surgery is recommended when the following conditions are present (1) The hyperplasia is confined to one quadrant of the unilateral breast, especially in the upper outer quadrant of the breast; the lump is large and hard, and the effect of conservative treatment is not obvious. ②Age >35 years old, with a family history of maternal breast cancer and a nodular breast lump, which has not been significantly reduced by various treatments. ③Existing hyperplastic breast lumps that increase rapidly within a short period of time. ④In the process of observation and treatment of existing breast hyperplasia, the symptoms and signs have recently increased, and the results of mammography and other imaging examinations such as mammography and needle aspiration cytology have shown progress compared with the previous examination, suggesting the possibility of malignant change. ⑤ Post-menopausal elderly women with newly developed “breast hyperplasia”, such as breast pain, glandular thickening, etc. ⑥Patients with mastoproliferative disease should undergo excision of the hyperplastic mass or simple mastectomy if it is confirmed by needle aspiration cytology or biopsy that the epithelial cells of the breast are actively proliferating or even starting to have heterogeneous changes. If necessary, intraoperative frozen section pathological examination should be performed.