Redness and swelling on both sides of the anus and pain from walking friction, first consider whether wearing too tight outer pants or underwear and walking for too long, resulting in repeated friction of the perianal skin during walking, causing redness, swelling and pain. If there is no clothing too tight factors, mainly suspected by the perianal disease, patients can be based on the following clinical manifestations for preliminary judgment and corresponding treatment: 1, hemorrhoids: is a common clinical anorectal disease, caused by pathological expansion of the venous plexus and connective tissue hyperplasia, often caused by bad defecation habits. Hemorrhoids are divided into external hemorrhoids, internal hemorrhoids and mixed hemorrhoids. Internal hemorrhoids and external hemorrhoids that prolapse out of the anus can easily cause anal redness and discomfort, moist and unclean, sometimes accompanied by itching and other performance, while walking due to clothing friction, which can lead to the appearance of pain. Patients can be examined by anal visualization and rectal examinations, local application of hemorrhoid cream and warm water sitz baths. If the redness and swelling increase and severe pain occurs, surgery can be taken to remove it; 2. Anal fissure: it is a chronic ulcer formed by skin rupture in the anal area, which can be caused by constipation, anal trauma, etc. The main manifestation is redness, swelling and pain around the anus, and the pain is mostly tear-like, knife-like and burning-like, which can be induced by walking, often accompanied by itching and blood in the stool. The main symptoms are redness and swelling of the perianal area, and continuous throbbing pain, hard nodes and pressure pain, which can be induced by walking and friction. If similar symptoms exist, prompt medical attention is needed to avoid further spread of the abscess, which can be applied topically by anti-infective creams such as erythromycin ointment, or surgical incision can be used to drain the pus. In addition, anal fistula and condyloma may also cause redness and swelling on both sides of the anus, and painful friction when walking. The causes are complex and varied, and may be difficult for patients to determine without professional knowledge, so a differential diagnosis should be made by a doctor if necessary, and timely treatment should be given.