The methods to interrupt the vertical transmission of hepatitis B virus from mother to child are: 1. Infants born to HBsAg negative pregnant women should be vaccinated with hepatitis B vaccine at 0, 1 and 6 months, respectively; 2. The infants born to HBsAg and HBeAg positive pregnant women should be injected with hepatitis B immunoglobulin l00ug within 6h and 1 month respectively, and be vaccinated with hepatitis B vaccine in the 2nd, 3rd and 6th months; 4. HBsAg positive pregnant women should insist on injecting 1 hepatitis B immunoglobulin every month from the 20th week of pregnancy. Besides, care should be taken to avoid damaging the mucous membrane of the baby’s mouth, pharynx, trachea, esophagus and stomach during delivery, postpartum feeding and nursing so that the hepatitis B virus in vaginal secretions, blood and breast milk will not enter the blood circulation through blood vessels and cause infection in the baby. The adoption of the above four types of blocking mother-to-child transmission of hepatitis B can control the epidemic of hepatitis B.