In winter and spring, people generally feel cold in the lower extremities, which is because the human lower extremities are farthest from the heart and the local blood flow is relatively slow. However, if the warming effect is very good, but still feel cold and numbness in the lower extremities, this abnormal cold lower extremities may be caused by some kind of disease. Common diseases include thrombo-occlusive vasculitis, except for occlusive atherosclerosis and diabetic foot in older people. The common diabetic foot is neuropathy vasculopathy resulting in lower limb infection, ulceration and deep tissue destruction, which is often clinically manifested as a result of peripheral neuropathy, nutritional deficiency, ischemia, foot deformity and infection, accompanied by severe pain, and continued development can lead to foot ulceration or even gangrene. Internal treatment with vasodilator drugs and neurotrophic therapy is usually ineffective, and it is also difficult to achieve sustained relief of vasoconstriction and pain, and to control the further development of lower limb ischemia. In the course of long-term treatment of such patients, our department found that the use of radiofrequency lumbar sympathetic ganglion modulation can not only dilate the blood vessels of the lower limbs, increase blood supply, play a nutritional and promote tissue repair. There is a significant change in the postoperative vasodilatation of the affected limb, and the skin temperature can rise by 2 to 4°C immediately. It also decreases the sensitization of inflammatory mediators, allowing persistent pain to be relieved. Adson and Diez found that resection of the sympathetic nerve was effective for lower extremity ischemia, and multiple case studies demonstrated that resection of the lumbar sympathetic nerve could resolve lower extremity ischemia and improve the patient’s symptoms. This pioneered the surgical treatment of ischemic diseases of the lower extremities. However, resection of the sympathetic nerve is a risky operation, with an operative mortality rate of 1.O% to 6.0%. Minimally invasive techniques emerged in the same period, and Brunn completed the first lumbar sympathetic nerve block in 1924. The results of the nerve block were found to be effective for ischemic diseases of the lower extremities. In recent years, radiofrequency thermocoagulation in sympathetic disruption was found to be significantly longer than the time of drug disruption. This procedure is simple and safe, so it can be performed repeatedly for lumbar sympathetic ganglion radiofrequency thermocoagulation disruption, and no death cases have been reported so far. Lumbar sympathetic ganglion is not only effective for diabetic foot, but also for (1) pelvic and lower extremity tumor pain sympathetic nerve persistent pain. (2) Lower limb ischemic pain: thrombo-occlusive vasculitis, lower limb Raynaud’s disease, refractory lower limb ischemic ulcers, frostbite, frostbite, Berg’s disease, erythematous limb pain, limb cyanosis, reticular cyanosis, pulselessness, venous thrombosis, thrombophlebitis, etc. (3) Lower limb neuralgia: burning neuralgia, amputation pain, phantom limb pain, injury neuritis, post-traumatic and surgical swelling and pain, post-herpetic neuralgia. (4) Lower limb hyperhidrosis, etc., the efficacy is also very significant.