The principles of treatment are to remove middle ear fluid, improve middle ear ventilation and drainage, control infection, and treat the etiology. 1. Non-surgical treatment (1) Antibiotic anti-inflammation for acute secretory otitis media (2) Short-term treatment with glucocorticoids. (3) Keep the nasal cavity and eustachian tube open with decongestants and blow the eustachian tube. 2.Surgical treatment (1) Tympanic membrane puncture to extract the fluid. If necessary, repeat the puncture and inject glucocorticoids, α-chymotrypsin and other drugs after the fluid is extracted. (2) If the fluid is viscous, the tympanic membrane cannot be aspirated or aspirated, or if the fluid accumulates rapidly after repeated punctures, tympanotomy is feasible. (3) If the disease persists for a long time, or if there are recurrent episodes of chronic secretory otitis media or glue ear, tympanotomy with tube placement is feasible. The duration of retention of ventilation tube is 6-8 weeks. (4) Others: Active treatment of nasopharyngeal or nasal diseases, such as adenoid scraping, nasal polyp removal, partial removal of inferior turbinate, nasal septum correction, sinusitis treatment, etc. (5) If chronic secretory otitis media is ineffective after various treatments and no obvious cause is detected, and early adhesive otitis media or cholesterol granuloma is suspected, tympanoplasty or simple mastoid opening is feasible.