Allergic purpura is a common vascular allergic disease. If a patient is in the acute phase of allergic purpura, vaccination with the New Crown vaccine is usually not recommended; however, if a patient is in the recovery phase or has a history of allergic purpura but has not had a relapse for a long time, vaccination with the New Crown vaccine is usually normal. Patients with allergic purpura are advised to consult their primary care physician promptly to clarify whether they can receive the vaccine. New crown vaccine acts on the immune system. Patients in the acute stage of allergic purpura have low body immune function, so vaccination with new crown vaccine at this time may increase the burden on the patient’s immune system and aggravate the disease or produce other adverse reactions. However, patients recovering from allergic purpura have gradually recovered their immune function, so it is safer to vaccinate with New Crown vaccine at this time. In addition, some medications used to treat allergic purpura may react with the New Crown vaccine, so patients are advised to stop taking the medication before receiving the New Crown vaccine, or to consult with their primary care physician about whether the medications they are taking and the New Crown vaccine can be used at the same time. In addition to the period of allergic purpura attack, there are also some cases that are contraindicated for the vaccination of New Crown vaccine, such as allergy to vaccine components, fever, presence of severe immunodeficiency, uncontrolled chronic diseases, as well as pregnancy and breastfeeding, etc. A doctor should be consulted before deciding whether to administer the vaccine.