Combination of Chinese and Western medicine for endometriosis

  The incidence of endometriosis (endometriosis for short) is on the rise among women of childbearing age and has become a “modern disease”. Endometriosis is a modern disease. 80% of patients have significant dysmenorrhea and 50% are infertile, seriously affecting the health and quality of life of young and middle-aged women. The main symptoms include dysmenorrhea, infertility and menstrual disorders. The dysmenorrhea is mostly secondary and progressive, radiating to the perineum, anus and thighs, with varying degrees and unbearable severity, accompanied by nausea, vomiting and diarrhea.  1. What is endometriosis Under normal circumstances, there is a layer of endometrium in the uterine cavity of women, but if the endometrium grows in other parts outside the uterine cavity, it is called endometriosis. Endometriosis belongs to the scope of “dysmenorrhea”, “Y obstruction”, “infertility” and “menstrual disorders” in Chinese medicine. It is a result of damage to the two channels of the Qi and Ren. It is due to the damage of the two channels of Chong Ren, the derangement of the uterine drainage, the menstrual blood does not follow the normal path and travels away from the menstrual channels, blocking the veins and arteries, stagnating into stasis, stagnating in the pelvic cavity, and the uncontrolled flow of Qi and blood, which can become Y. Therefore, stasis of blood becomes the most important pathological basis of this disease. However, the formation of blood stasis is often related to the dysfunction of the body’s internal organs and the loss of harmony between qi and blood, especially with kidney deficiency and liver depression. Modern Chinese medicine practitioners believe that there are four main types of endo-stasis: damp-heat and blood stasis, cold-clotting and blood stasis, qi stagnation and blood stasis, and kidney deficiency and blood stasis. The incidence rate among women of childbearing age is 10%, and in recent years the incidence has been on the rise worldwide, and is classified as one of the common and difficult diseases. It has become a hot and difficult issue in the field of gynecology because of the uncertainty of its etiology, pathogenesis and standard treatment.  2. Specific clinical manifestations and signs of endometriosis The clinical manifestations of endometriosis mainly include dysmenorrhea with persistent lower abdominal pain, painful intercourse, pelvic mass, infertility and menstrual disorders. In endometriosis, dysmenorrhea is mostly secondary and progressive, radiating to the perineum, anus and thighs, with varying degrees of severity, unbearable, accompanied by nausea, vomiting and diarrhea, requiring bed rest or medication for pain relief. Dysmenorrhea and pelvic masses are one of the main points in the diagnosis of endometriosis, and infertility is an important complication in up to 50% of cases. About 20% of patients may have no obvious symptoms.  Signs: In typical pelvic endometriosis, the pelvic examination shows uterine adhesions, posterior fixation, slightly enlarged uterus, cystic solid inactive masses attached to the uterus with light pressure pain, and hard nodules of irregular shape ranging from rice grain to bean size with obvious tenderness are found in the rectal recess of the uterus, uterosacral ligament, and lower part of the posterior wall. In large ovarian endometriotic cysts, a cystic mass may be found in the abdomen. Lesions involving the rectovaginal diaphragm may be palpable or even visible as a prominent purplish nodule in the posterior vaginal vault. Ectopic sites in other areas such as abdominal wall scar and perineal incision may have enlarged tender nodules during menstruation that shrink after menstruation.  Laparoscopy and intraoperative biopsy are the “gold standard” for the diagnosis of endometriosis; imaging diagnosis is most commonly performed by B-type ultrasound scanning of pelvic masses; magnetic resonance imaging (MRI) is more accurate for the diagnosis of endometriotic cysts; there are no biochemical indicators for the diagnosis and monitoring of endometriosis. There are no biochemical indexes that are valuable for diagnosing and monitoring the progress of endometriosis, such as CA125, anti-endometrial antibody, anti-cardiolipin antibody, etc. may be elevated, but the specificity of these indexes are not high.  4.Treatment of endometriosis by combining Chinese and Western medicine Endometriosis faces many problems, not only the pathogenesis is a mystery, the clinical manifestations are diverse, the symptoms are intense and stubborn, and the behavior is similar to malignant tumors such as dissemination, implantation and metastasis, but also the treatment of endometriosis is imperfect and unsatisfactory, although there are drugs, surgery and radiotherapy, etc., but no matter what kind of treatment is given, endometriosis The overall recurrence rate is up to 50% or more, and eradication is at the cost of loss of ovarian function. Treatment of endometriosis should achieve 4 goals: to reduce and relieve pain; to reduce and remove ectopic endometrial lesions; to restore normal anatomy and reproductive function; and to prevent and reduce recurrence.  To this end, scholars have proposed 5 best treatments: laparoscopy; ovarian suppression; “triphasic therapy”; pregnancy; and pregnancy assistance techniques. The choice of treatment should also be individualized according to the patient’s age, fertility requirements, severity of symptoms, and the condition such as the extent, location, bulk and microscopic morphology of the lesion.  The treatment includes expectant therapy, surgical treatment and pharmacological treatment.  (1) Expectant therapy: Early cases can be treated with expectant therapy, but endometriosis is a progressive disease, and if the symptoms and signs increase, active therapy should be used instead.  (2) Surgical treatment: Surgical treatment is currently classified as conservative (preservation of reproductive function), semi-radical (removal of the uterus and preservation of ovarian function) and radical surgery (removal of the uterus, ovaries and the lesions seen), but all have a certain chance of recurrence, especially conservative and semi-radical surgery.  (3) Pharmacological treatment: To achieve ovarian suppression, or “pseudo-pregnancy” or “pseudo-menopause”, the drugs commonly used today are progestin, danazol, endometrium and gonadotropin-releasing hormone agonist (GnRHa).  The treatment of endometriosis with TCM is holistic, macroscopic and proactive, with long-term efficacy and no obvious toxic side effects. It is effective for mild patients, while moderate and severe patients can improve their symptoms and reduce their pain. The main symptom of this disease is blood stasis evidence, and throughout the course of the disease, the initial stage is dominated by actual evidence, and the disease is prolonged and injures the righteousness, resulting in deficiency due to actuality and manifesting mixed evidence of deficiency and actuality, and pure deficiency evidence is rarely seen. According to the characteristics of dysmenorrhea, menstrual flow, duration of the disease and concurrent evidence, we can identify the symptoms in Qi and blood, cold and heat, kidney deficiency and liver depression, and treat the whole body by draining liver and Qi, clearing heat and cooling blood, warming menstruation and dispersing cold, tonifying kidney and benefiting Qi, resolving phlegm and softening hardness. The aim is to regulate immune function, endocrine regulation, control inflammation, and improve blood rheology. The treatment is mainly based on evidence-based treatment supplemented by Chinese herbal medicine, with the hospital’s homemade preparation of anti-cellulite punch, which is effective in the treatment of endometriosis. The course of treatment is usually three months, and one or two courses of treatment are needed to see results. It is worth emphasizing that endometriosis is a clinically difficult disease, and the long-term results are not very satisfying, whether treated by Chinese medicine alone or Western medicine alone. The organic combination of Chinese and Western medicine, giving full play to their respective advantages and complementing each other’s shortcomings, can improve the curative effect.