The causes of impotence in men in their 50s include age, physical illness, and other factors. The causes of premature ejaculation include psychosomatic factors, over-sensitive penile sensation, and diseases of the external genitalia and prostate. 1. Causes of impotence (1) Age: the older you are, the more likely you are to develop erectile dysfunction. (2) Physical diseases: such as cardiovascular disease, diabetes, urogenital diseases, renal insufficiency, hyperlipidemia, obesity and so on. (3) other factors: such as mental psychological factors, poor lifestyle, trauma, surgery or other medical factors. 2. Causes of premature ejaculation (1) Spiritual and psychological factors: such as depression, anxiety, anxiety, hostility, and so on. (2) Penile sensation is too sensitive or penile sensory nerve excitability is increased: research shows that patients with premature ejaculation have a significantly shorter sensory evoked latency of the head of the penis than normal people. (3) Diseases of external genitalia and prostate: such as phimosis, glansitis, prostatitis and other organic lesions. Patients with impotence and premature ejaculation occurring in their fifties should go to the hospital in time, and standardize their treatment under the guidance of a doctor.