Penile horn is a hard protrusion that grows on the glans penis, coronal sulcus, etc. It is grayish-yellow or yellowish-brown with clear borders and can reach several centimeters in size. Although penile horn itself has no blood flow and can fall off on its own, giving people the feeling of self-healing, it is actually an illusion because it is a precancerous lesion of benign tumor and is very prone to recurrence, so thorough treatment of it should not be neglected because it falls off on its own, otherwise it may develop into cancer or potential cancer. The treatment of penile horn is different from that of penile sclerosis. Its complete treatment can include local excision of normal tissues at the base of the lesion or early partial penile excision, which should be followed up closely after the operation. Although this disease is not rare, how to treat it promptly and correctly is still a problem that patients should pay attention to.