Celecoxib, as a nonsteroidal anti-inflammatory analgesic, is less irritating to the gastric mucosa and is better tolerated by patients using it because it is a cyclooxygenase 2 inhibitor. However, even so, long-term use is not recommended in the absence of contraindications and obvious adverse effects, and it is recommended to reduce and discontinue the dosage promptly after the improvement of joint symptoms. Celecoxib inhibits prostaglandin production by inhibiting cyclooxygenase-2, which has anti-inflammatory, anti-rheumatic and analgesic effects. It is mainly indicated for the relief of joint symptoms such as osteoarthritis, rheumatoid arthritis and ankylosing spondylitis; it can also treat acute pain such as acute ankle sprain, acute shoulder tendonitis and bursitis. Osteoarthritis and rheumatoid arthritis can be applied for 2-4 weeks; if ankylosing spondylitis is not effective after 4 weeks, the dosage can be increased appropriately for a period of time as prescribed by the doctor, and if it is still not effective, it is necessary to go to the rheumatology department in time to change the treatment plan under the guidance of professional doctors. Although celecoxib has a small side effect rate of less than 2%, it should not be used for people with active peptic ulcers or bleeding. In addition, people who are allergic to sulfonamides, aspirin and other NSAIDs should also avoid using this drug.