Although Parkinson’s disease is currently incurable and may seriously affect the daily life and work of patients and even cause disability, Parkinson’s disease itself is not a fatal disease and generally does not affect life expectancy, with a small number of patients living into their 80s and 90s. The average life expectancy of female patients is longer than that of men. With the emergence of new therapeutic drugs and treatments, more and more patients are able to maintain a high level of motor function and quality of life for a longer period of time. According to statistics, in the era before the application of levodopa therapy, patients with Parkinson’s disease had a shorter life expectancy and their mortality rate was three times higher than that of the general population. However, after the application of levodopa replacement therapy, the mortality rate of patients with Parkinson’s disease was approximately the same as that of the general population. Therefore, it is very important to apply anti-Parkinson’s disease medication such as levodopa and dopamine agonists, while patients should not worry that having Parkinson’s disease will affect their life expectancy. Although the disease itself is not fatal, due to the presence of motor and coordination disorders, patients are more prone than the general population to accidents such as falls and serious complications such as pneumonia, fractures, urinary tract infections, and asphyxia, all of which can be direct causes of death. If patients do not receive timely and reasonable treatment, it will easily lead to the decline of physical functions and even the inability to take care of themselves, with a high disability rate and a long disease course, causing great suffering to patients and a serious burden to their families and society. In addition, researchers are currently working to find new treatments that can inhibit the degeneration of brain cells and stop the progression of the disease at the source, thus achieving active treatment instead of the current passive symptomatic treatment. At the same time, early diagnosis of Parkinson’s disease, early prevention of movement disorders, and treatment of psychiatric symptoms and dementia can all help improve the quality of life for people with Parkinson’s disease. Both patients themselves and their families should take care to reduce negative emotions such as depression and anxiety and face life positively and optimistically!