The sudden swelling and thickness of the upper lip is not painful, and the common cause may be angioedema due to allergy, which is also seen in granulomatous labyrinthitis. You should go to the hospital in time to determine whether it is caused by simple allergy or related to bacterial or viral infection, and take appropriate measures, such as the application of drugs or surgical treatment, so as not to delay treatment and further development of the disease. 1. Angioedema: usually caused by allergy, in addition to the mouth and lips, can also occur in such as eyelids, scalp, tongue, throat, patients feel that the upper lip suddenly swells thick without pain, and may have numbness, swelling The patient may feel numbness and swelling. First of all, allergens need to be identified, common allergens include seafood, penicillin, pollen, mites, sunlight, cold air, etc. After determining the allergen, you should disengage from it in time and apply anti-allergy drugs such as chlorpheniramine, montelukast, loratadine, etc. under the guidance of a doctor to control the allergy symptoms in time so that the condition will not continue to develop. Daily attention should be paid to stay away from allergy-inducing factors and avoid washing the lips with hot water or scratching the lips; 2. Granulomatous labyrinthitis: Most of them occur in youth or middle age, both upper and lower lips may occur, but most of them occur in the upper lip, which is manifested as swelling of the upper lip without pain or itching, and there is no depression under pressure. The swelling that occurs in the early stage of the disease can subside on its own, but if it recurs and is not treated in time, it may progress to a giant lip and even spread to the adjacent skin. Hormonal medications such as prednisone, tretinoin, and hydrocortisone can be used under medical supervision. If there is an oral infection, antibiotics such as metronidazole and minocycline may be given as appropriate for treatment. If giant lips are formed, surgical repair can be considered. Attention should be paid to avoid overly dry lips, ensure sufficient water intake every day, and avoid bad habits such as lip licking and lip biting. In addition, when some children drink bottled water or use small caliber water cups to drink water, the mouth of the bottle is sucked on the upper lip, which can lead to blood leakage from the capillaries of the upper lip due to the negative pressure inside the bottle, resulting in swelling, which is manifested as a sudden swelling of the upper lip without pain or itching, accompanied by redness and swelling, usually without abnormal sensation, which does not require treatment and can subside on its own after some time.