Timely diagnosis and timely treatment of Parkinson’s disease (PD) patients is the best way to improve their quality of life. I have been doing PD research and treatment for more than ten years, and I come into contact with thousands of patients from all over the country every year, and I am well aware that PD patients endure pain that is difficult for ordinary people to understand, and that such pain is like a shadow that follows them; although surgical treatments are very effective for primary PD, the number is still very small and insignificant. Even the Department of Functional Neurosurgery at Xuanwu Hospital of Capital Medical University, which performs more than 300 surgeries per year, is still not enough for the thousands of PD patients. The majority of patients can only be relieved with medication; at the same time there are many patients who are not diagnosed and lose the best opportunity to relieve their symptoms in time. Therefore, the most important thing for Parkinson’s patients is to be diagnosed in time. Jianyu Li, Department of Functional Neurosurgery, Xuanwu Hospital of Capital Medical University As the incidence of Parkinson’s is only 1%, not all patients or their families are clear about the symptoms of PD. The purpose of this article is to let PD patients and their families, or people who are suspected of having PD, understand the symptoms of PD and cooperate with the doctor for diagnosis and timely judgment. Doctors with extensive clinical experience should first differentiate between Parkinson’s disease and Parkinson’s syndrome, primary tremor and stroke. The doctor will ask the patient the following questions: 1, inquire about the patient’s symptoms, including tremor, rigidity and bradykinesia, etc.; 2, the duration of the disease for several years; 3, from which side of the disease; 4, medication taken and drug response; 5, the next is to check the patient’s physical examination to see if the patient’s eye movements, muscle strength, muscle tone and balance are not impaired; 6, and in addition to ask the patient has no history of intoxication or poisonous substance exposure. Experienced doctors will pass the first question to ask, can probably determine whether the patient suffers from PD, and the patient and family members as long as the doctor accurately answer whether the following symptoms: unilateral or bilateral arm will be involuntary shaking, muscle pain or the body can not be straightened, whether the foot curled up, difficult to start, etc., can be. The latter questions are intended to differentiate between primary Parkinson’s disease and Parkinson’s syndrome, as the treatments for these two conditions are different. PD does not usually have symptoms such as balance disorder, dysphagia, incontinence, etc., except for tremor, rigidity and retardation and postural disturbances. In addition, primary Parkinson’s disease usually responds better to medications, and the course of the disease progresses relatively slowly, whereas medications in general do not have a satisfactory effect on Parkinson’s syndrome. Primary Parkinson’s disease usually starts unilaterally and then involves the other side, while most patients with the syndrome have little difference in symptoms between the two sides. In addition, the syndrome is usually characterized by rigidity and bradykinesia, and rarely by tremor…. Myotonia is one of the main symptoms of PD; the doctor may examine the patient’s muscle tone and feel for cogging in order to rule out any subjective errors on the part of the patient. In addition, some doctors sometimes use other auxiliary means of judgment, such as PET-CT, and MRI, and we usually do a head MRI before the operation. Accurate diagnosis is the first step in the treatment. Patients and their families should understand the characteristics of PD (see http://www.neurosurgery.org.cn/index.asp for more specialized and accurate information), and work together with their doctors to overcome the disease during the treatment and rehabilitation process. Nowadays, many patients or family members consult with the relevant doctors through the Internet, so an accurate and detailed description can be a great convenience for you. For this reason, I have created a table that will be able to give a complete representation of the patient’s disease. Although Parkinson’s Disease PD cannot be completely cured, doctors and patients can minimize the pain and improve the quality of life when they work together. I believe that with the development of technology, the closer to the origin of PD Parkinson’s pathogenesis, there will be more means to deal with it! SCHEDULE: Many patients and their families, nowadays, make their initial inquiries to their doctors through the Internet. For this reason, I have prepared a detailed questionnaire form that can be prepared to describe the disease by simply checking the box or simply filling it in. Walking forward Yes□ No□ No□ Reduced facial expression Yes□ No□ Urinary and fecal incontinence Yes□ No□ Slurred speech Yes□ No□ Difficulty in swallowing Yes□ No□ Age of onset Duration of disease Duration of disease: within 6 months□, 6 months to 3 years□, more than 3 years□ Side of symptom Unilateral disease□ Bilateral disease□ Both sides of the disease are similar in severity□, one side is mild, the other side severe □ Medication Medoba □ Dosage per session: times: BENING □ Dosage per session: times: Amantadine □ Dosage per session: times: amantadine □ Dosage per session: time: time: time: time: time: time: time: time: time: time Toxic substances: yes□ Carbon monoxide poisoning yes□ no□ no□ Past history Traumatic brain injury□ Stroke□ □ Meningitis Medical treatment 1, Time: Hospital: 2, Time: Hospital: 3, Time: Hospital: Diagnostic findings/protocols 1, 2, 3, Therapeutic effects 1, 2, 3, Other tests Cranial CT yes□ no□ MRI yes□ no□ Other: