Patients who suspect breast cancer through self-examination or doctor’s examination may undergo imaging or endoscopic means to make a preliminary diagnosis. Further diagnosis requires biopsy and whole-body multi-site examination to determine the stage and the hormone receptor status of the lesion to determine whether endocrine therapy is appropriate. Knowing the methods of breast cancer examination and having appropriate examination in time when abnormalities are detected can help breast cancer patients get early detection and treatment, thus achieving better treatment results. Specific methods are as follows: 1. Mammography Mammography is a non-invasive method. The Siemens-ElemaAB mammography machine is simple and easy to operate, and its mammogram is clear, rich in levels and informative, which is of great significance for screening breast diseases, especially early breast cancer. 2.Ultrasound imaging Ultrasound imaging is a non-invasive examination, and generally ultrasound is the first examination method for breast enlargement examination, which is simple, accurate, and can be used dynamically and repeatedly. Breast duct endoscopy Breast duct endoscopy can observe the epithelium and duct lumen of the breast ducts of patients with nipple overflow under direct vision, which greatly improves the accuracy of the diagnosis of the cause of nipple overflow patients and accurately locates the diseased ducts, which is of great help to surgical treatment. Endoscopic examination of breast ducts is helpful for early detection of intraductal carcinoma with nipple overflow, especially in patients with intraductal carcinoma who do not see calcified foci on mammography, which shows unique superiority. Biopsy (1) Mass excision: The whole mass or suspicious tissue in the breast is excised for pathological examination. (2) Excisional biopsy: A portion of tissue is excised from the lump or suspicious tissue for examination. (3) Coarse/fine needle aspiration: Using a very fine needle to extract some tissues and cells from the lump, suspicious tissues or fluid accumulation for examination. Because of easy operation and high accuracy, aspiration biopsy has been one of the most common examination measures for breast cancer diagnosis. Other, such as smear cytology examination of nipple overflow, scraping or print cytology examination of nipple erosion part can be done. (4) Molecular typing examination: estrogen and progesterone receptor and HER-2 receptor determination Molecular typing is a new typing method that has emerged in recent years and is very important for determining prognosis. After breast tumor removal, estrogen, progesterone and HER-2 receptor levels in the tumor are measured, and if the receptors are expressed at high levels, endocrine therapy or monoclonal antibody Herceptin therapy can be administered. Of course, recent studies have shown that lapatinib, a small molecule tyrosine kinase inhibitor, has also shown good efficacy in HER-2-positive breast cancer patients, especially when both HER-1 and HER-2 are positive, so lapatinib may be used when HER-1 and EGFR are positive.