Tumor thermotherapy (hyperthermia) is a method of applying various heat sources combined with modern medical science and technology to heat malignant tumors. Some scholars call it “warm treatment of cancer”, “high heat treatment of cancer”, “transheat treatment of cancer”, etc. In terms of hyperthermia itself, it is a purely physical treatment. In terms of heat therapy itself, it is a purely physical treatment, and the heat sources include high-frequency electromagnetic wave, infrared ray, ultrasonic wave, hot water bath and so on. When heating the body, due to the unsound tissue structure of the tumor tissue itself, the heat dissipation is slower than that of normal tissues, which makes the temperature of tumor tissues higher than that of normal tissues by 5℃~10℃, and the malignant tumor cells are sensitive to the high heat, as a result, the tumor cells are killed or apoptotic gradually after the high heat, while the normal tissues are not damaged. The unique advantage of thermotherapy relative to radiotherapy and chemotherapy is that it has no toxic side effects. At the same time, thermotherapy can enhance the immune ability of the body and increase the efficacy of radiotherapy and chemotherapy, which can reduce the recurrence of tumors, improve the quality of survival of tumor patients and prolong the survival period. Five major roles of thermotherapy against tumors 1. The direct role of high heat on tumor cells Research shows that high heat can directly kill tumor cells, inhibit the synthesis of deoxyribonucleic acid (DNA), ribonucleic acid (RNA) and proteins; high heat can damage the normal function of cell membranes, change the permeability of cell membranes, cause protein spillage, and change the structure of nuclear chromosome, which will lead to the death of cancer cells. Because the internal structure of tumor tissue is not sound, high heat inhibits the respiration of tumor cells, enhances the anaerobic fermentation to make the pH drop, and strengthens the activity of lysosome to cause the death of tumor cells; due to the inhibition of protein synthesis, it also inhibits the proliferation of tumor cells, and causes the death of tumor cells. All of these are most sensitive to the S phase of cell proliferation, which can be tens to hundreds of times different from other phases. This is because radiation therapy and many drugs are effective on cell proliferation cycles other than the S phase. Such a complementary and synergistic relationship has an important therapeutic value in clinical practice. 2, heat therapy to increase the effect of chemotherapy Research shows that 42 ℃ in vitro for 120 minutes can make some chemotherapeutic drugs to enhance the effect of cancer 10 to 100 times. In clinical application, heat therapy and chemotherapy combined application, its efficacy is much greater than the sum of two kinds of efficacy. In the case of achieving the same therapeutic index, the dosage of chemotherapeutic drugs can be reduced, thus reducing the harm to human body. Heat therapy can increase the effect of radiotherapy. Heat therapy and radiotherapy have different sites in the cell proliferation cycle, i.e. heat therapy is sensitive to the cell cycle and radiotherapy is not sensitive to the cell cycle, which forms a complementary relationship. Heat therapy can also change the histological and physiological characteristics of the tumor, which in turn can enhance the effect of radiotherapy. 4, Thermotherapy affects the body’s immunity in the special biological characteristics of the tumor tissue has a different reaction from the normal tissue, the result is to accelerate the death of the tumor tissue. Heat therapy eliminates toxins in the body The human skin provides protection for the whole body, which is both an absorbing organ and an excretory organ. In whole-body heat therapy, the human body discharges a lot of sweat, and the pores that usually cannot be opened will be opened to the maximum extent, and the toxic substances absorbed by the body and skin will be discharged at the same time when a large amount of sweat is discharged, which saves the body from the stimulation of toxic substances and achieves the purpose of preventing diseases.