I was often called by sister departments to consult cancer pain patients and found that the patients still complained of pain despite the many medications, and the pain seriously affected their sleep at night, which made the patients suffer and their families tormented. However, my analgesic prescriptions can basically help patients to sleep peacefully within a short period of time with significant pain relief. Is there a secret to my analgesic prescriptions? The key is to adjust the prescription according to the patient’s condition, and the key is to be “fast”, for patients with severe pain we run into three steps. The first step is to give non-opioid (non-steroidal anti-inflammatory drugs) plus or minus adjuvant painkillers for mild pain. Note: There is a problem of maximum effective dose (ceiling effect injection) of non-steroidal analgesics. Commonly used drugs include paracetamol, aspirin, diclofenac, plus Hepatitis B, ibuprofen, fenpropathrin (ibuprofen extended-release capsules), anti-inflammatory pain, indomethacin, Isidin (indomethacin controlled-release tablets), etc. Weak opioids plus or minus NSAIDs and adjuvant analgesics are given for moderate pain in the second tier. Weak opioids also have a ceiling effect. Commonly used drugs include codeine, prednisolone, tramadol, chimantin (tramadol extended-release tablets), diclofenac (codeine controlled-release tablets), etc. Third order severe pain is given with opioids plus or minus NSAIDs and adjuvant analgesics. Strong opioids have no ceiling effect, but can produce tolerance and require appropriate dose increases to overcome tolerance. Drugs commonly used in this ladder include morphine tablets, morphine sulfate controlled-release tablets, oxycodone controlled-release tablets, fentanyl transdermal patches, etc. However, dulcolax, a commonly used painkiller in the past, is not recommended for the control of chronic pain because of the high toxicity of its metabolites, which can lead to addiction and dependence. In addition to the three-step drug analgesia for cancer pain, epidural analgesia, block or destruction of visceral plexus or ganglion, morphine pump placement analgesia, etc. are often used in our department.