Mastocytosis is most often seen in middle-aged women and tends to be less common after menopause. Its typical presentation is breast swelling 7 to 10 days before the onset of menstruation, often accompanied by breast discomfort or pain, or the appearance of breast nodules. The diagnosis is usually not difficult to determine based on the medical history and physical examination. However, many patients ask for an instrumental examination, the purpose of which is to find out if there is breast cancer or if it will develop into breast cancer at the same time The presence or absence and severity of breast enlargement pain is not absolutely related to the presence, size and number of nodules. The condition can also be very inconsistent in both breasts. It is very common to have pain without nodules on one side and nodules without pain on the other side. In women with both nodules and pain, the nodules and pain may or may not have a largely synchronized pattern of change. For example, nodules can increase in size and hardness before menstruation, and pain can also appear and worsen, sometimes due to certain nodules. Pressure on these nodules can often cause or worsen the pain. The pain can involve the armpits, upper extremities, shoulders or back, and in some cases can be very severe. The pain and nodules may subside completely or partially after menstruation. However, in some women, the periodicity of the pain and nodules can be very unexplained. Some patients may not show nodules, but may be characterized by localized glandular thickening and similar cyclical changes. The condition of mastocytosis often fluctuates. Mental stress, emotional stress, overexertion, irregularity in life, and especially the use of diet pills or so-called health supplements may become triggers for it. Clinical examination of mastocytosis may reveal no abnormalities, or it may reveal limited or diffuse glandular thickening, toughening, or hyperplastic nodules in the breast. Hyperplastic nodules are often striated, granular or lamellar in shape, and are often irregular in shape. The texture of the nodule is tougher than normal tissue, and individual nodules may be harder and more painful to the touch. Nodules may be single or multiple, and may vary in shape, size, and texture within the same breast, or may exist at the same time. A small number of patients may also have nipple discharge. The color of the overflow is plagioid or straw-yellow transparent, and bloody overflow is rare. The treatment of mastocytosis is mainly psychotherapy. The disease is self-limiting, and for those with a history of six months or less, symptoms can be reduced within three months by relieving mental stress, maintaining a stable mood, regulating life patterns, paying attention to work and rest, adopting a low-fat diet, and using less or no health care products, and generally no medication is necessary. Many behaviors that are conducive to establishing a pleasant and regular life and work order are beneficial in relieving breast swelling and pain. Therefore, believing and making efforts to carry out self-regulation will yield good results. Placebo without any drug ingredients is often very effective in the management of breast enlargement symptoms. There are dozens of medications available to treat breast enlargement, but none of them can make the symptoms disappear completely or cease to appear. Temporary relief and remission with medication is followed by the reappearance or worsening of some of them. Relying solely on medication without self-adjustment makes it difficult to achieve solid long-term results. The vast majority of patients with breast enlargement do not require surgical treatment. Surgical treatment is only indicated for those with high risk factors and a localized lump with very pronounced symptoms. The surgical approach is mastectomy of the breast area. Another important purpose of surgical treatment is to obtain breast tissue for pathological examination to rule out the possibility of breast cancer. Surgical removal of the segment does not eliminate breast pain and it is more difficult to prevent the appearance of new nodules. The key issue is to inform women that the vast majority of breast enlargement is not pathological, and even those with pathological diagnosis of enlargement may not be pathological. This is because almost everyone in the adult female population has a similar clinical or pathologic presentation, including all women with any symptoms in the breast. Having symptoms of breast enlargement does not mean that the breast itself is diseased, but rather that there is some trigger for endocrine disruption in the breast. This is the same as when we have difficulty sleeping when we are overexcited, it does not mean that there is something wrong with the brain. Just like the brain excitement, the symptoms of breast enlargement will be relieved to some extent by itself after the corresponding triggers are removed. It is easy to understand whether mastocytosis will develop into breast cancer. Statistics show that women who have symptoms of breast enlargement have the same chance of developing breast cancer as women who do not have symptoms of breast enlargement. This means that mastocytosis itself will not develop into breast cancer. A portion of patients who develop breast cancer do so because of the presence of high-risk factors. Therefore, if you are suffering from breast enlargement, you should first eliminate your worries, treat breast enlargement correctly, maintain a good state of mind, and pay attention to adjusting your emotions and life pattern. Those who have symptoms of breast enlargement will be relieved soon. May all women have a good mood, eliminate the concern that mastocytosis will become cancer, and live a healthy and happy life.