There are more causes of unilateral nipple itching, mainly including clothing stimulation, nipple skin diseases, nipple inflammation, breast tumors, etc., which can be treated according to different causes with causal intervention: 1. Clothing stimulation: women’s underwear of inappropriate size or not worn well, resulting in unilateral nipples being subjected to local friction of intimate clothing, which can lead to itching, and it is recommended to choose suitable underwear again; 2. Nipple skin diseases: unilateral nipples Allergies, eczema or excessive dryness in the area can lead to itchy nipples, commonly seen in diseases such as nipple eczema and nipple fungal infections. The nipple itself has more skin folds, especially in the hot weather and humidity, it is easier to breed pathogenic bacteria due to local humidity, itching and discomfort, but also accompanied by obvious skin flaking, should pay attention to skin hygiene; 3, nipple inflammation: If the unilateral nipple is damaged due to breastfeeding, trauma and other circumstances, bacteria can easily enter the nipple from the dilated duct, which can then cause nipple inflammation, itching It is mainly seen in eczema-like breast cancer, which is a special type of low-grade malignant breast cancer, probably due to the infiltration of large ductal carcinoma of the breast under the unilateral nipple into the nipple, resulting in nipple lesion.