What are the current effective domestic treatments for multiple sclerosis (MS): I. Allopathic treatment: including immune intervention therapy 1. How to recognize the application of hormones in the treatment of MS? First, hormone therapy is not a panacea. Glucocorticoids are limited to the treatment of acute MS attacks and relapses – they help to rapidly improve symptoms, reduce the more serious consequences of disease attacks and shorten the course of acute attacks, but they do not help to reduce the frequency of relapses in patients and have no effect on the entire natural course of MS disease. Secondly, the application of long-term high-dose glucocorticoids may produce serious side effects, such as peptic ulcer, osteoporosis, femoral head necrosis, hypertension, diabetes, infection, psychiatric symptoms, etc. These adverse effects even exceed the harm of MS disease itself. At present, the best solution recommended by domestic and foreign experts is short-term high-dose shock therapy (relatively small adverse reactions). 2. In what way can we prevent MS relapse and slow down the disease progression in order to improve the quality of life? Disease Modification Therapy (DMT) The first-line drugs currently available in China are: Betaseron and Librium, which are relatively expensive and have relatively few side effects; second-line drugs such as Mitoxantrone and other immunosuppressive drugs, which are economically priced but have relatively large adverse effects. According to domestic and foreign research and experience, MS patients usually have the highest frequency of relapse in the early stage of the disease (within 3 years after the first attack), so we suggest to use the drugs as early as possible to stop the progress of relapse, reduce the occurrence of dysfunction, reduce the disability rate and improve the quality of life. 3. How long does treatment take and under what circumstances should a change in treatment plan be considered? Theoretically, MS is a lifelong disease, and we hope that patients can adhere to DMT treatment if the treatment is effective, but considering the economic situation, we recommend that patients with early treatment should adhere to it for at least 3 years. A change in treatment regimen should be considered when: (1) an intolerable adverse reaction occurs; (2) the patient has an increased number of relapses; or (3) the disease continues to progress. In case of relapse during DMT treatment, DMT medication should be temporarily discontinued and short-term corticosteroid shock therapy and symptomatic treatment should be applied according to the situation, and DMT treatment should be resumed after the symptoms are stabilized. Symptomatic treatment includes symptom improvement (e.g., painful spasm control, fatigue reduction), as well as rehabilitation and psychological adjustment, etc. This requires the collaboration of neurologists, rehabilitation trainers and psychologists, especially rehabilitation training is a very important part for MS patients. Overall, with the continuous progress of medical technology, the range of treatment options for MS patients is gradually expanding. Although this disease cannot be cured, early and reasonable treatment can significantly improve the patient’s quality of life, and we hope that patients will not be blindly pessimistic or avoid medical treatment, but will have a correct and objective understanding of this disease and suggest confidence to overcome it.