The larger the handwriting (capitalism) is one of the clinical manifestations of cerebellar ataxia causing disorders of random motor coordination, which is an ataxia of the ipsilateral limb caused by damage to the cerebellar hemispheres. So how to diagnose and treat capitalization disorder? Diagnosis of capitalization disorder examination: 1. Isolated kidney function is good and generally difficult to detect. Often for some reason, one kidney is found to be absent when performing B-type ultrasound or CT examination of both kidneys. 2.The triangle is asymmetric during cystoscopy, and one side of the ureteral orifice is absent. 3.Urogram and intravenous urography show no renal shadow or no shadow on one side, and compensatory enlargement of the contralateral kidney. It should be noted that other causes of renal failure should be excluded, such as advanced renal tuberculosis and renal hypoplasia. 4, retroperitoneal gas injection angiography, B-type ultrasound and CT examination show no kidney on one side. Should be differentiated from symptoms caused by cerebellar ataxia causing random motor coordination disorder. Capitalization treatment care: Ataxia is currently available in addition to general support therapy, acupuncture treatment, physical therapy and functional exercise of the limbs, but also a variety of B vitamins, cytidine phosphorylcholine injection, oral lecithin, etc.. In China, there are reports of good results in the treatment of ataxia with TMES therapy. In late stage patients, attention should be paid to the prevention of various infections. Arch foot orthopedic surgery or orthopedic shoes are feasible. The disease develops slowly, and most of them do not affect their life expectancy if there are no serious cardiopulmonary complications. A small number of patients are bedridden and crippled. As neural precursor cells with the potential to self-renew and differentiate into neurons, astrocytes and oligodendrocytes, neural stem cells have a wide range of clinical applications. The differentiated neurons from stem cell transplantation replenish the reduced brain cells, and the secreted neurotrophic factors promote the function of nerve cells in cerebellar tissues, which can repair and improve the neurological diseases structurally and functionally, thus improving the control dysfunction of the cerebellum and achieving the effect of treating ataxia.