In the late stage of glioma, there will be increased intracranial pressure, headache, vomiting and mental symptoms, etc. On the other hand, local symptoms will appear due to the pressure and infiltration of brain tissues by the tumor, which will cause neurological function damage. 1.Increased intracranial pressure may produce optic papillae edema, which may lead to secondary atrophy of optic nerve and decrease of visual acuity. Tumor compression of the optic nerve can produce primary optic nerve atrophy, which also leads to vision loss. The adductor nerve is easy to be pressed and squeezed, which often leads to paralysis and diplopia. Headache is mainly caused by increased intracranial pressure. The intracranial pressure gradually increases when the tumor grows, which compresses and pulls the pain-sensitive intracranial structures. The headache may be mainly on the affected side, intermittent at the beginning, mostly occurring in the early morning. With the development of the tumor, the headache will be gradually aggravated and prolonged in duration. Vomiting is caused by the stimulation of the medullary vomiting center or vagus nerve, which may not be preceded by nausea and is projectile. In children, the headache is not obvious due to the separation of cranial sutures, and the vomiting is more prominent due to the prevalence of tumors in the posterior cranial fossa. Some tumors, especially those located in the frontal lobe, may gradually present psychiatric symptoms, such as personality change, indifference, decreased speech and activities, poor concentration, memory loss, lack of concern for things, and lack of neatness. Epilepsy A part of tumor patients have epileptic symptoms, which can be early symptoms. Epilepsy starts from adult who is usually symptomatic, mostly caused by brain tumor. If it is not easy to be controlled by drugs or the nature of seizure is changed, the presence of brain tumor should be considered. Local symptoms Local symptoms will produce corresponding symptoms according to the location of the tumor and aggravate progressively. Especially malignant glioma grows faster, infiltrates and destroys the brain tissue, and the surrounding brain edema is obvious, the local symptoms are more obvious, and the development is also very fast. In the early stage of intraventricular tumors or tumors located in the quiet zone, there may be no local symptoms. On the other hand, tumors in the brainstem and other important functional areas will show local symptoms in the early stage, and symptoms of increased intracranial pressure will appear only after a considerable period of time. Patients with advanced gliomas also need treatment to relieve their symptoms and prolong their survival.