1, fasting or after meals to take the drug? Aspirin is hydrolyzed into salicylic acid in the body after taking, causing digestive tract irritation; in addition, pharmacologically speaking, aspirin reduces the production of prostaglandins, which have a protective effect on the gastric mucosa, by inhibiting cyclooxygenase. Therefore, some people recommend taking it after meals to reduce gastrointestinal irritation. However, the emergence of enteric formulations has changed the traditional way of taking drugs. Enteric aspirin is minimal in the gastric contents, so most of them are required to be taken on an empty stomach, which allows the drug to enter the intestine quickly and take effect. Moreover, aspirin is used for anticoagulation prophylaxis, and each dose of 50-100 mg can cause minimal damage to the gastric mucosa. However, how much of the enteric tablets are enteric, how much is dissolved and absorbed in the stomach, no one can say, if the patient has ulcerative disease or gastrointestinal function is not good, or take it after meals. 2, morning or evening take the drug? The mechanism of aspirin as a cardiovascular event prevention drug is its anti-platelet effect, and this effect is irreversible, throughout the life cycle of platelets, and the cycle of platelet regeneration to about a week, aspirin anticoagulant effect and pharmacokinetics is not consistent. Long-term use of extended-release preparations, the effective blood concentration in the body is relatively constant, and for patients on long-term medication, there should be no problem of disparity in efficacy between morning and evening dosing. Therefore, in a nutshell, if there are no contraindications to the use of the drug, aspirin can be taken at any time.