There is no such thing as the best way to open lower extremity vein thrombosis. For the treatment of lower extremity venous thrombosis, it is mainly thrombolysis or surgical removal, and requires drug anticoagulation to prevent thrombosis. It is necessary to choose the suitable treatment method according to the different conditions of the patients, such as surgical treatment, interventional therapy, anticoagulation therapy and so on. 1. Surgery: If it is a superficial vein thrombosis in lower limb, it can be removed by surgery, including varicose vein and superficial vein thrombosis can be removed together, so as to achieve the purpose of complete treatment. 2. Interventional therapy: if the thrombus is in deep veins of lower limbs, thrombolysis can be done through tubing under intervention, although the effect is remarkable, but the time for tubing thrombolysis is relatively longer, and it usually takes 6-12 hours to thrombolysis. 3. Anticoagulation therapy: If the thrombosis is chronic, especially if the time of thrombosis is more than one month, the thrombosis of lower limb veins can be opened by anticoagulation therapy, such as taking warfarin and hydroclopidogrel. If patients want to open the lower extremity venous thrombosis, it is recommended to go to the hospital for a detailed examination to clarify the type of disease, and choose the best program for symptomatic treatment under the guidance of the doctor.