The application of immunosuppressive drugs for nephrotic syndrome is very important, and it can be said that without the use of immunosuppressive drugs, the relapse of nephrotic disease cannot be avoided. The most commonly used clinically is cyclophosphamide, but in general people think these drugs have a lot of side effects and are reluctant to use them. In fact, these drugs are very safe if used properly. What should be noted in the use of these drugs? A single dose and the relationship between the total dose: According to personal experience, the cumulative dose of these drugs and the relationship between the inhibition of relapse is more closely, and the relationship between the single dose and side effects is more obvious, the larger the single dose the more obvious the side effects, a single application of 0.8g or more, there are gastrointestinal reactions in about 80%, while 0.4g is rarely adverse reactions, to a smaller dose slowly accumulate, to a certain dose will It will produce good effect after reaching a certain dose. Second, the relationship between hormones and immunosuppressants: hormones can produce good immediate effects due to the good inhibition of the inflammatory response, which is a curative treatment measure, but often reduce the amount of easy to relapse, resulting in repeated doses, resulting in serious side effects. Immunosuppressants act on immune cells, inhibit lymphocyte proliferation and antibody synthesis, and play a curative role. Together, they complement each other and become two indispensable aspects. In the process of CTX slowly accumulating, the hormone will be slowly reduced to achieve a smooth treatment process. Third, pay attention to the protection of reproductive function: the most worrying thing for patients in the use of drugs is the impact on fertility. I think that curing the disease is the first, and fertility is the second, which is a rather sensitive topic. In the process of actual application, we still need to pay attention to the maintenance of the patient’s reproductive function, then it is to insist on the long-term use of Chinese herbs with reproductive function protection, such as Chinese wolfberry, Xuan Shen, |Silk, Xian Ling Spleen, etc., especially for children, in the course of treatment. After years of observation, as long as this is done, the effect on reproductive function is minimal. The cure of nephrotic syndrome is almost impossible without the use of immunosuppressants. The optimal dose required varies from patient to patient; CTX, for example, requires at least 3 grams, and in many cases up to 30 grams or more. Vincristine is similar in effect to cyclophosphamide, with fewer side effects. A few patients may require more than two immunosuppressive combinations to achieve efficacy. Urine microalbumin should be used as a follow-up indicator when the routine urine protein test turns negative, and urine microalbumin should be considered for discontinuation only when it remains negative for more than six months. Urine microalbumin should only be discontinued if the patient has been normal for more than three years after fever or strong exercise.