In recent years, the introduction of new antiviral drugs for hepatitis C, direct antivirals (DAAs), such as sofibuvir, has provided a new means of treatment for hepatitis C. From the initial interferon and ribavirin based with DAA, to the interferon-free regimen in the last two years, it has improved the efficacy while bringing light to patients with contraindications to interferon, interferon non-response, and relapse after interferon therapy. Although DAAs are not yet available in China, many patients have already purchased their own medication from India, Bangladesh and other countries through friends, relatives or surrogates. However, drugs are not chewing gum, and the treatment process should be guided by a doctor, and the following points must be noted: I. Efficacy of DAAs: Available clinical data show that DAAs-based treatment regimens have a sustained response (meaning that hepatitis C RNA remains below the detection range for 24 weeks after discontinuation) rate of about 90%, and treatment guidelines in Europe and the United States and other countries have made DAAs-based treatment the The treatment guidelines in Europe and the United States have identified DAAs-based therapy as the preferred treatment option for hepatitis C. Although such drugs are not yet available in China, the latest 2015 guidelines for the treatment of hepatitis C also make recommendations for this therapy. However, it is important to note that regular review is still needed after treatment, especially for patients with cirrhosis, even if the virus is cleared, there is still a risk of complications of cirrhosis and liver cancer in the future, and regular review is very important. Second, the treatment plan of DAAs: the treatment plan and course of treatment are different for different conditions and different drugs. Before starting treatment, detailed examinations should be done, including hepatitis C RNA, hepatitis C genotyping, liver and kidney function, blood routine, ultrasound, liver hardness test, etc. The treatment process should also be closely monitored and regularly reviewed to evaluate its efficacy and adverse reactions. The whole process of treatment should be carried out under the guidance of doctors. Adverse reactions of DAAs: Overall, DAAs are better tolerated and have fewer adverse reactions than interferon, but there are still some adverse reactions, especially when combined with some drugs, such as anti-HIV drugs, antidepressants, cardiovascular system drugs, lipid-lowering drugs, immunosuppressants, etc., which may aggravate the adverse reactions, and the doctor should explain in detail the combination of other diseases and The use of drugs. Fourth, the quality of drugs varies: because DAAs are not listed in China, patients purchase their own drugs, some patients buy directly from overseas through friends and relatives, in the process of purchase should pay attention to choose the local authoritative medical institutions or pharmacies; there are some patients through a variety of commercial agency purchase, know that this agency purchase is strictly illegal, and the quality of drugs is difficult to guarantee, it is best to learn more from other patients who have experience in purchasing drugs to avoid being cheated. It is best to learn more from other patients who have experience in purchasing drugs to avoid being cheated.