Somatoform disorder, formerly known as “insidious depression”, is characterized by a persistent fear or belief that the patient has one or more physical illnesses. Therefore, the patient repeatedly reports somatic symptoms, constantly requests medical examination and treatment, and does not believe in the negative results of repeated examinations (no disease detected), even though the doctor repeatedly explains the symptoms and that there is no basis for organic disease, the patient still cannot dispel the doubts. These patients often visit the doctor repeatedly, each time describing their symptoms in as much detail as possible, fearing that the doctor will not listen carefully and misdiagnose their disease, often feeling discomfort in one or more parts of the body, constantly checking and treating in general hospitals, constantly changing hospitals, some will go to Beijing, Shanghai and other large hospitals for examination and treatment, some treating for more than 3 years, mostly without seeing improvement. Even so, they are reluctant to see psychiatric psychiatry, they think they have a physical disease, not related to psychology. For this reason, they waste a lot of medical resources and spend a lot of energy to go to the doctor, and over time, it will cause family conflicts, and some family members will say that the patient is not sick and pretend to be sick, etc. The patient feels very aggrieved and thinks that her family does not understand her, etc. So how should this disease be treated? The treatment plan of this disease is as follows: 1, “venlafaxine” from the small amount of 25mg in the evening 25mg, after meals, three days later changed to 25mg in the evening 50mg, after the condition can be added every three days 25mg, up to 100mg in the evening 150mg. half a tablet before lunch and dinner “Shubili”. If sleep is not good night can take 1-2mg clonazepam, about 1-4 weeks gradually reduce stop clonazepam. Hypertensive patients “venlafaxine” should not exceed 75mg/day, if taking this drug blood pressure continues to rise should stop using. 2.Escitalopram + a small amount of “olanzapine”. 3.Sertraline + small amount of “aripiprazole”. 4.Mirtazapine treatment. The first one of the above options should be chosen first, if the full dose treatment is not effective for 4-8 weeks, the next option is available. At the same time, some patients can cooperate with psychotherapy to reduce their excessive concern about the body, accept the “symptoms”, live and work with the “symptoms”, and let the “symptoms” disappear gradually in work and life. “gradually disappear.