If you find clusters of tiny calcified foci distributed during screening and classified as grade 4, then a biopsy is required. Then you are faced with the choice of which biopsy method to undergo. The traditional method of surgical biopsy is to locate the calcified foci with a metal needle puncture under a mammogram and then surgically remove the calcified foci and the surrounding tissue before performing a biopsy. This method has been used for nearly half a century. It is recognized as the “gold standard”. The advantage is that the lesion and its surrounding tissues can be completely excised, the calcified lesion is intact, and the diagnosis is not easily missed. The disadvantage is that too much tissue is removed and the location of the lesion in the specimen is difficult to determine precisely. In recent years, our team has done special research to address its disadvantages and completed an improvement of the traditional surgical biopsy method with the support of provincial research projects in Zhejiang Province. Our method is called “Double Needle Positioning Rotary Biopsy Method for Breast Microcalcification Lesions”. Compared with the traditional method, the new method has more accurate positioning, smaller resected specimens, and the location of the lesion in the specimen is very clear. It will not miss the diagnosis. It has been promoted for use. Of course, you can also choose the vacuum-assisted puncture biopsy method, which has become more popular in recent years. It has the advantage that the skin wound is very small and the lesion tissue can also be excised. The disadvantage is that the lesion is shredded into a strip of tissue and there may be residual lesions. Biopsy of breast lesions includes both of these types of methods, and both are now widely used in clinical practice. Don’t forget that you have a choice.