Chronic renal failure, also known as chronic renal insufficiency, is a progressive destruction of the kidney caused by various kidney diseases, which is irreversible and incurable, but can be treated for the primary disease and complications that cause chronic renal failure to control the condition and delay further deterioration of kidney function. Treatment needs to be tailored to the patient’s individual situation, and common treatments include early prevention and treatment, drug therapy and renal replacement therapy, as well as adjustment of nutritional intake. Early prevention and treatment: There are many causes of chronic renal failure, so the treatment of chronic renal failure should first be directed at the primary disease. If the chronic renal failure is caused by hypertension, blood pressure should be strictly controlled by antihypertensive drugs. If it is caused by diabetic nephropathy, it should be treated with sugar-lowering therapy. For chronic kidney failure caused by chronic nephritis, try to control the protein intake of patients. Second, drug therapy: drugs help prevent complications, control blood pressure, correct water, electrolyte and acid-base balance. Commonly used diuretic drugs to relieve the body’s water-sodium imbalance; sodium bicarbonate and other drugs can relieve the symptoms of metabolic acidosis caused by the disease; Sevelamer, calcium acetate and other drugs can be used to regulate the calcium-phosphorus balance in the body; medicinal charcoal tablets, uremic pellets and other drugs to reduce creatinine and protect the kidneys. It is also necessary to consider whether to add antibiotics, antihypertensive, and drugs to improve anemia according to the specific conditions of patients. Third, renal replacement therapy: 1, dialysis treatment: hemodialysis, peritoneal dialysis and other methods can be used to artificially replace the kidneys to remove excess metabolic waste, but also to improve kidney function and improve the quality of survival of patients; 2, kidney transplantation: kidney transplantation can help restore kidney function, but the kidney source is difficult to find, there may also be post-operative rejection reaction, etc. It is recommended that patients choose according to their actual situation and condition. Fourth, nutritional intake: daily diet should pay attention to limit the intake of salt, potassium, phosphorus and protein, quit smoking and alcohol to avoid causing adverse reactions of the body. Especially for uremic patients, limiting protein intake can effectively reduce the discharge of nitrogen-containing metabolites and avoid the occurrence of uremic encephalopathy.