Mental stress can definitely lead to infertility. In normal life, mental stress can delay menstruation, and in severe cases, it can cause menstrual disorders. In the clinic, it can often be seen that women with normal menstruation have poor follicular development or even no ovulation when monitoring ovulation or performing artificial insemination. The mechanism of these occurrences may be due to endocrine changes caused by mental stress. We know that the regularity of menstruation is controlled by the hypothalamic-pituitary-ovarian axis. Changes in hormone levels (including estrogen, progesterone, follicle-stimulating hormone, luteinizing hormone) determine the development of the follicle and the discharge of the egg, as well as the growth, maturation and shedding of the endometrium, and changes in the cervical mucus. These factors affect the operation of sperm in the female genitalia, sperm-egg binding and embryo implantation, and it is often seen in the clinic that some couples who are infertile for no obvious reason become pregnant again after adopting a child, which is also a proof of infertility caused by mental stress. Therefore, in the treatment of infertility, mental factors should not be ignored.