When cancer cells spread, it often indicates that the disease has entered the middle and late stage. Due to the different cancer sites, the body releases different signals. In addition to the primary site of cancer, the metastatic site of cancer cells spread will also show corresponding symptoms, and some systemic symptoms will also accompany. I. Local symptoms 1. Brain metastasis: if cancer cells spread to the brain, the common symptoms are vomiting, headache, loss of vision, hearing, speech, cognition and memory impairment; 2. Chest metastasis: if cancer cells spread to the chest, the common symptoms are chest pain, vomiting, loss of appetite, pleural effusion, difficulty in breathing, hemoptysis, etc.; 3. Abdominal metastasis: if cancer cells spread to the abdomen, the common symptoms are abdominal distention, ascites, loss of appetite, etc. Bone metastasis: metastasis of cancer cells to the abdomen often manifests as pain and osteoporosis at the metastasis site, and in serious cases, fracture may occur. Second, the systemic reaction of cancer is usually in the middle and late stage. No matter metastasis or spread occurs in any part, the whole body will show different degrees, such as fever, weakness, body pain, weight loss, non-healing trauma, or lymph node mass, etc. As mentioned above, cancer cells spread and the body’s reaction performance is still relatively obvious in the middle and late stages. If patients have the above symptoms, they should seek medical treatment immediately to clarify the cause of the disease. If diagnosed, attention should be paid to follow medical advice to actively carry out treatment and regular review in order to promote recovery.