Ceftriaxone sodium for injection Trade name: Safoxin, Rosetin [Pharmacology and Toxicology]: This product is a third generation cephalosporin antibiotic. It has strong activity against Enterobacteriaceae bacteria. The MIC90 of Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Bacillus flurodii citrate, Indole-positive Aspergillus, Prevotella spp. and Serratia spp. is between 0.12~0.25mg/L. Enterobacter cloacae, Bacillus immobilis and Pseudomonas aeruginosa have poor sensitivity to this product. It has strong antibacterial effect on Haemophilus influenzae, Neisseria gonorrhoeae and Neisseria meningitidis, and also has good effect on Streptococcus haemolyticus and Pneumococcus. The MIC for Staphylococcus aureus is 2-4mg/L. Methicillin-resistant Staphylococcus and Enterococcus are resistant to this product. Most of Bacteroides fragilis are resistant to this product. Pharmacokinetics】: Intramuscular injection of 0.5g and 1g of this product, the peak blood concentration (Cmax) is reached after about 2 hours, 43mg/L and 80mg/L respectively. 24 hours after intra-muscular injection of 0.5g, the blood concentration is 6.0 mg/L, the blood elimination half-life (t1/2b) is 7.1 hours. 0.5g of intra-muscular injection within 1 minute, the immediate peak blood concentration (Cmax) is 150.9mg/L. The immediate peak blood concentration (Cmax) at the end of the drip was 150.7 mg/L and the blood concentration at 24 hours was 9.9 mg/L, with a blood elimination half-life (t1/2) of 7.87 h. The peak blood concentration (Cmax) at the end of the drip was 150.7 mg/L and the blood concentration at 24 hours was 9.3 mg/L when 0.5 g was administered intravenously over 30 minutes. After the administration of 20 mg/kg daily to patients with septic meningitis, the 6-hour brain