There are currently eleven major classes of hypertensive drugs, five commonly used: diuretics, beta-blockers, calcium channel antagonists (CCB), angiotensin inhibitors (ACEI), angiotensin receptor blockers (ARB), and six other classes: alpha 1 receptor blockers: such as prazosin, central antihypertensive drugs: such as colistin, vasodilators: nitroprusside, Chinese herbal antihypertensive drugs: such as niuhuang hypotensive pills, enzymes Antihypertensive drugs: such as pancreatic kininogenase, others: such as reserpine. Here mainly introduces the five categories of drugs commonly used. I. Diuretics: there are thiazides, tab diuretics and potassium-protective diuretics. The main ones are hydrochlorothiazide, spironolactone, indapamide. The antihypertensive efficacy of various diuretics is similar, and the antihypertensive effect is mainly through drainage, reducing extracellular volume and lowering peripheral vascular resistance. The onset of antihypertensive effect angle is gentle, the duration is relatively long, the effect is long-lasting, and the effect reaches its peak after 2-3 weeks of taking the drug. It is suitable for all degrees of hypertension, especially in the presence of heart failure. The main adverse effects of these drugs are hypokalemia and effects on lipid, blood glucose and uric acid metabolism. Gout patients are prohibited. Second, beta-blockers: commonly used are metoprolol, atenolol, bisoprolol, carveolol. The effect of antihypertensive may be through the inhibition of central and peripheral RAAS. antihypertensive effect is more rapid and powerful. It is suitable for various severity of hypertension, especially for middle-aged and young patients with fast heart rhythm or combined with angina pectoris, but relatively less effective in elderly people with hypertension. The main adverse effects of these drugs are bradycardia and increased insulin resistance, and can increase airway resistance, so in acute heart failure, bronchial asthma, pathological sinus node syndrome, atrioventricular block and peripheral vascular disease patients are prohibited. Calcium channel blockers: also known as calcium antagonists, mainly nifedipine, amlodipine, verapamil and diltiazem. According to the duration of drug action, calcium channel blockers can be divided into short-acting and long-acting. The advantages over other antihypertensive drugs are better antihypertensive efficacy in elderly patients and high sodium intake does not affect the antihypertensive efficacy. The main adverse effects are swelling and increased heart rate, facial flushing and headache in some patients at the beginning of treatment. Use with caution in patients with heart failure, sinus node dysfunction or heart block. Angiotensin-converting enzyme inhibitors: commonly used are captopril, enalapril and benazepril. ACE inhibitors have the effect of improving insulin resistance and reducing urinary protein, especially for hypertensive patients with cardiac hypertrophy, heart failure, myocardial infarction, reduced glucose tolerance or diabetic nephropathy. Adverse effects are irritating dry cough and angioedema. Contraindicated in hyperkalemia, pregnant women and patients with bilateral renal artery stenosis. V. Angiotensin II receptor antagonists: commonly used are crosartan, telmisartan, irbesartan. These drugs have a slow onset of antihypertensive effect, long-lasting and stable. These drugs do not cause irritating dry cough. They are contraindicated in patients with hyperkalemia, pregnant women and bilateral renal artery stenosis.