Primary thrombocythemia cannot be cured, but the condition can be effectively controlled by medication and plateletpheresis. 1. Drug therapy: commonly used drugs include myelosuppressive drugs and anti-platelet aggregation drugs. (1) Myelosuppressive drugs: for example, hydroxyurea, interferon-alpha, etc., used to inhibit the abnormal proliferation of bone marrow. (2) Antiplatelet aggregation drugs: such as aspirin, clopidogrel, etc., used to prevent platelet aggregation. 2. Platelet isolation: it can rapidly reduce the number of platelets and improve the symptoms. It is commonly used in gastrointestinal bleeding, pregnancy and childbirth, before elective surgery. If primary thrombocythemia is diagnosed, it is recommended to standardize the treatment under doctor’s guidance to control the condition in time.