SLE has a certain genetic predisposition, but it is not a genetic disease in the traditional sense, but a polygenic genetic disease. The results of familial SLE surveys show that there is a 5-10% family aggregation of SLE, a 1-10% prevalence in first-degree relatives of SLE patients, and dizygotic studies confirm a 24% concordance for monozygotic twin SLE and a 2% concordance for dizygotic twins. However, most cases do not show heritability. The genetics of SLE is complex and includes several genes in which the major histocompatibility complex (MHC) plays a role; in addition, complement genes, inflammation-related genes, hormone genes, and some genes on the X chromosome all play a role. The above statement may be abstract, in other words, a patient with SLE will not necessarily pass it on to the next generation, but the chances of the next generation getting the disease are higher than normal.