Cervical lymph node malignant tumor in advanced stage is generally not curable, and it needs anti-tumor treatment, such as chemotherapy, radiotherapy, targeted drug therapy, etc., according to the primary site of the tumor and the type of pathology. Cervical lymph node malignant tumor, may be the primary tumor of the neck, may also be caused by other parts of the tumor metastasis, staging belongs to the late stage, most patients can not be cured. Treatment first needs to clarify the pathological type of the tumor and determine the primary site of the tumor. Evaluate the patient’s physical condition, as well as cardiopulmonary, hepatic and renal functions and other indicators. For the advanced stage of cervical lymph node malignant tumor, systemic chemotherapy and local radiotherapy can be considered. According to the results of genetic testing, combined use of targeted drug therapy and so on. Neck lymph node malignant tumor advanced stage generally poor prognosis, take anti-tumor treatment, may appear blood system, gastrointestinal adverse reactions, should pay attention to observation. It is recommended to go to regular hospitals for standardized treatment in time to avoid delaying the condition.