Drug rashes in children do not heal on their own and require prompt action to prevent a life-threatening condition. The most important thing is to stop using the drug that causes the drug rash; in order to promote the excretion of the drug, you should drink a lot of water, intravenous input of the appropriate amount of fluid; mild drug rash using small doses of glucocorticosteroids (such as Dinaid cream), severe use of high-dose glucocorticosteroids, such as Prednisone, and so on. Parents should pay attention to give the children enough nutrients and encourage a reasonable diet; follow the doctor’s instructions to give good skin care, such as the use of boric acid lotion, saline and other wet compresses. Clinical manifestations of drug rash are more, serious cases involve other systems, even life-threatening, so should go to regular hospitals for treatment in a timely manner, under the guidance of professional doctors to choose the appropriate treatment to improve the quality of life.