Symptoms of liver pain in patients with liver tumors usually do not depend on the size of the tumor, but are generally related to the location of the tumor growth and inflammation in the liver. When suffering from a liver tumor, as the tumor grows it will cause the hepatic peritoneum to be stretched, thus causing symptoms of liver pain. Excessive tumor growth can cause necrosis and liquefaction within the tumor and secondary infection. When infection occurs in the liver, it can lead to liver cell damage, thus creating the symptom of pain in the liver area. Some patients can also cause liver pain in the late stage of the tumor. When a liver tumor is diagnosed, it should be treated in time. In the early stage, it can be treated by surgery. If the disease is in the middle or late stages, chemotherapy should be administered using drugs such as cisplatin carboplatin. When the liver pain is severe, it can be treated with Tramadol and other drugs for pain relief. Patients should seek medical treatment when they feel unwell to avoid aggravation of the disease.