Blisters caused by fungal infections should be avoided by avoiding scratching and visiting the hospital promptly for treatment under a doctor’s supervision, including oral and topical medications. Skin fungal infections have a long treatment period and may cause other diseases, so they should be treated promptly when found. Topical medications include clotrimazole, miconazole, etc. Generally, less irritating creams are preferred for treatment. When topical medications are not effective, oral medications such as itraconazole and fluconazole can be taken under doctor’s supervision. If the blister ruptures inadvertently, it should be sterilized with iodophor immediately to prevent bacterial infection. Patients with fungal skin infections should follow the doctor’s instructions to standardize the treatment. During treatment, the skin should be kept as dry and clean as possible, and care should be taken to avoid breakage of the blisters.