The so-called “major tri-positive” and “minor tri-positive” are the common names for the two common results of hepatitis B “two-and-a-half” test, in which the three indicators of hepatitis B surface antigen (HBsAg), e antigen ( The three indicators of positive hepatitis B surface antigen (HBsAg), e antigen (HBeAg) and nuclear antibody (anti-HBc) are “major triple-positive”; the three indicators of positive hepatitis B surface antigen (HBsAg), e antibody (anti-HBe) and nuclear antibody (anti-HBc) are “minor triple-positive”. It is generally believed that “major triple-positive” is mostly accompanied by positive hepatitis B virus deoxyribonucleic acid (HBV-DNA), which means that the hepatitis B virus (HBV) in the patient’s body is actively replicating and is highly infectious; while “minor triple-positive” means that the virus replication in the body has basically If the HBV-DNA is negative, the patient is basically not infectious. ”The difference between “major triplet” and “minor triplet” is that the former The difference between “major third-positive” and “minor third-positive” is that the former is positive for e antigen (HBeAg) while the latter is positive for e antibody (anti-HBe). Among the indicators of the “two-and-a-half” test, e antigen is an important marker of viral replication, and its presence indicates that the virus is actively replicating in the body. The e antibody is an antibody produced by the body’s immune system under the stimulation of the e antigen, and its appearance indicates that the body has developed a certain degree of immunity to the e antigen, and viral replication is inhibited and basically stopped. Therefore, the “small triplet” is usually transformed from the “large triplet”, which is generally considered to be relatively more contagious and has a higher likelihood of becoming chronic hepatitis B. The “minor triplets” are less contagious. Which is more serious, “major triple-positive” or “minor triple-positive”? Because the “major triple-positive” virus replication is active, highly contagious and very easy to become chronic hepatitis; while the “minor triple-positive” virus replication basically stopped, if coupled with “HBV-DNA” negative The virus is basically not infectious. Therefore, many patients and even health care professionals believe that the condition of “major third-positive” is more serious than “minor third-positive”, as long as the “major third-positive” can be converted to ” The “small triple-positive” will be good enough. Whether it is “major triple-positive” or “minor triple-positive”, it only reflects the status of the virus carried in the body and does not reflect the normal function of the liver, and therefore cannot be used to determine the severity of the disease. What really determines the severity of a patient’s condition is the HBV-DNA, liver function and clinical symptoms. There are roughly the following three situations: 1, some “small three yang” patients are still positive for HBV-DNA, suggesting that viral replication is still active. This situation is often the result of virus mutation, the patient’s body immune system can not effectively inhibit the replication of the virus. In this case, the patient’s condition develops faster and more seriously, and should be noted; 2. Whether “major triplet” or “minor triplet”, as long as the liver function is normal, and there are no obvious symptoms, can be called hepatitis B virus carriers. Most of these people were infected with the hepatitis B virus during infancy and childhood, and because the body’s immune system is not yet mature, it is incapable of completely removing the hepatitis B virus and living peacefully with it for a long time. This situation generally does not require the use of antiviral treatment, but it is necessary to regularly go to a regular liver disease specialist hospital to receive “two pairs of half” and “liver function” examination, as well as early detection of disease fluctuations, to take treatment measures; 3, if ” If a patient with “major tri-positive” or “minor tri-positive” has repeatedly abnormal liver function, or clinical symptoms, or enlarged liver and spleen, he/she should be judged to be a hepatitis B patient and be actively treated to control active liver disease as soon as possible, so as to avoid the development of cirrhosis and liver cancer in the course of long-term recurrent active liver disease. Is it necessary to switch from “major triple-positive” to “minor triple-positive”? ”If the conversion from “major triple-positive” to “minor triple-positive” is completed before the age of 25-30, the process of virus clearance is completed for the body and the damage to the liver is less severe. If “major triple-positive” is transferred to and fro, or “major triple-positive” continues, and the clearance reaction (hepatitis continues to be active and transaminases repeatedly rise) continues, then around the age of 40, for most patients, even if they are converted to “minor triple-positive”, they will have different degrees of liver fibrosis or cirrhosis. If the “major triple-positive” continues for life, without significant hepatitis activity (liver function is always normal), perhaps they can still live until the age of 60-70. The “big three” does not always have to be converted to “small three”. The change from “big three yang” to “small three yang” is a manifestation of the body clearing the virus, but the liver damage brought about should not be taken lightly. Medical research proves that after a certain period of time, 5-10% of “major triple-positive” people naturally turn into “minor triple-positive” every year. The natural conversion is a chance for every person with “big three”, but there is no way to determine exactly when it will happen. Therefore, patients with “major triple-positive” should take a scientific view of their condition and not worry too much, and not try to use antiviral drugs to turn “major triple-positive” into “minor triple-positive” when the liver function is normal. “This is to prevent the drugs from causing secondary damage to the liver and aggravating the condition. How to treat “major third-positive” and “minor third-positive”? The “big three yang” and “small three yang” make the majority of patients live in the shadow at all times, bringing a lot of inconvenience to normal work and life, how to treat the “big three yang” has become a Many patients are concerned about how to treat “major and minor triple yang”. However, because there is no drug that can penetrate deep into the liver cells to remove the virus, the effect of traditional therapy on the treatment of “large and small triplets” is not satisfactory.