Parkinson’s disease, also known as tremor palsy, is a chronic progressive disease of the nervous system that occurs mostly in middle-aged and elderly people, with an average age of onset of 55 years and an increasing incidence with age. It is a degenerative disease of the nervous system that is mainly characterized by involuntary shaking of the arms and legs (tremor), stiffness of the limbs and trunk (muscle rigidity), and delayed or reduced movement (hypokinesia). The disease not only affects the motor system, but also other systems, manifesting as some non-motor symptoms such as anxiety and depression, sleep disorders, constipation, cognitive decline and even dementia. Professor Xu Guozheng, director of neurosurgery at Wuhan General Hospital of Guangzhou Military Region, introduced that the number of Parkinson’s disease patients worldwide has exceeded 4 million, and in China has exceeded 2 million, with nearly 100,000 people becoming new Parkinson’s disease patients every year. The disease has a high incidence and high disability rate, which seriously affects the quality of life of middle-aged and elderly people, so it is very important to achieve early identification, early diagnosis and early treatment. Parkinson’s disease starts insidiously, and many patients with Parkinson’s disease initially only show non-motor symptoms such as depression, insomnia, and loss of smell, which are often difficult to identify. Minimally invasive DBS instead of disruption Several generations of experts from the National Institute of Neurosurgery and the Department of Neurosurgery of Wuhan General Hospital of Guangzhou Military Region have conducted in-depth research on the trends of Parkinson’s disease, treatment pathways and surgical medications, and have carried out more than 100 cases of “stereotactic microelectrode localization intracranial nucleus disruption” since 1997. Recently, we have carried out the minimally invasive “deep brain electrical stimulation” surgery, commonly known as DBS surgery. During the operation, doctors use an electrode needle like acupuncture to slowly implant specific nuclei in the brain, and bury a pulse generator under the skin of the chest to electrically stimulate the nuclei for treatment purposes. In this way, the symptoms of Parkinson’s disease, such as incessant shaking and abnormal movement, are significantly improved or even disappeared. Compared to the past, when Parkinson’s disease attacks were suppressed by directly destroying the nerve tissue in the brain, DBS surgery is more effective, less invasive, more reversible, and much safer. Many patients find that after 5 years of taking medication for Parkinson’s disease, the effect of the medication gradually declines and the tremors in the limbs cannot be controlled even if the dose is increased. Therefore, Parkinson’s disease, mobility disorders and other diseases, in the early drug effective. DBS surgery is recommended later when the efficacy wanes or drug complications arise. Parkinson’s patients are considered to have the best results when surgery is performed when the medication begins to wane, but is not yet completely ineffective. If the patient is already suffering from long-term uncontrolled, neurological damage or disability caused by disease progression, further surgery will not be helpful. Professor Xu Guozheng said: Parkinson’s patients once the drugs gradually lose their efficacy, if the adjustment of drugs still can not achieve the therapeutic effect, it will seriously affect the patient’s quality of life, therefore, in the absence of contraindications to surgery should be operated as soon as possible. Parkinson’s disease requires “both internal and external” Parkinson’s disease is not a single discipline pathology, it involves neurology, neurosurgery, psychology and other disciplines. Professor Xu Guozheng pointed out that Parkinson’s disease cannot be cured by medication or surgery alone, but requires a combination of medical and surgical treatment. Internal medicine controls the disease, the initial drug control, the dosage adjustment according to the individual, the drug intake after surgery, etc.; surgery should strictly guard the “threshold” of DBS (i.e., patients with primary Parkinson’s disease and those who have good response to levodopa), and only patients who meet the requirements of surgery can undergo surgical treatment, and the postoperative period should also be adjusted according to the condition. After surgery, the stimulation parameters and medications should be adjusted according to the disease, along with rehabilitation and psychological treatment, which can improve the quality of life of patients and enhance the treatment effect.