Many times we do not pay much attention to the sore throat, often take some medicine or go to the pharmacy to get some medicine, or as a common cold to the internal medicine department, do not know that a huge risk to health and life hidden in it? The most common acute inflammatory disease in otorhinolaryngology with sore throat as the first symptom is acute epiglottitis. Acute epiglottitis is one of the most serious clinical diseases in otorhinolaryngology, characterized by rapid onset and rapid and dangerous development. It is not uncommon in clinical practice, and can occur in both adults and children, with early symptoms of sore throat, which are often overlooked by patients and parents. The early symptoms are only sore throat, which is often neglected by patients and parents. In the early stage, there is usually no dyspnea and little hoarseness, and the disease often develops with the stimulation of colds or smoke. If doctors diagnose the disease only according to this diagnosis without laryngoscopy, it often results in delayed diagnosis and treatment, and most of the patients are misdiagnosed as having colds or pharyngitis due to the absence of laryngoscopy. Indirect laryngoscopy is a routine examination for diagnosing acute epiglottitis, which is simple and easy to perform, and it is easy to see the swollen lingual surface of epiglottis, and sometimes it is possible to see swollen aryepiglottic folds and arytenoid cartilage. Treatment focuses on keeping the airway open and fighting infection. The combination of adequate antibiotics and steroids is currently the most commonly used regimen for the pharmacologic treatment of acute epiglottitis. Patients with particularly rapid progression should be hospitalized for observation and be ready for tracheal intubation or tracheotomy. Therefore, the first sign of a sore throat should be to the otolaryngologist.