Cell therapy is a kind of adjuvant therapy for tumors that has emerged in recent years, and is regarded as the fourth major treatment for tumors after surgery, chemotherapy and radiotherapy. The main types of cell therapy used in the past two or three decades are: 1. natural killer cells (NK) 2. lymphokine-activated killer cells (LAK) 3. tumor-infiltrating lymphocytes (TIL) 4. 4, CD3 monoclonal antibody-activated killer cells (anti-CD3 antibody-activated killer cell, CD3-AK) 5, cytocine induced killer cells (CIK) 6 These immune cells have the function of killing tumor cells and adjuvant chemotherapy, and each of them has its own advantages and disadvantages in clinical use. In recent years, a new type of cell therapy has been developed, namely, antigen-loaded DC-CIK cells (Ag-DC-CIK cells) for tumor treatment. It has been found that such cells have stronger and more specific tumor-killing activity than the immune cells previously used in tumor therapy, and have received more attention from tumor workers, and have been widely used in the treatment of adult liver cancer, lung cancer, kidney cancer, leukemia, lymphoma and other tumors. At present, our department has carried out Ag-DC-CIK cell therapy for retinoblastoma.