Retinoblastoma is a common malignant tumor in the pediatric eye that can cause loss of vision and even life. Parents usually see the doctor because they find a white reflection in the center of their child’s “black eye”, or “cat’s eye”, as the saying goes, but often the tumor in the eye has almost filled the entire eye by the time the cat’s eye is found, and vision is almost lost. For retinoblastoma, early detection is necessary for better treatment, and early detection of retinoblastoma depends mainly on regular fundus screening. In fact, very few parents are able to insist on regular fundus examinations for their children. Fundus examinations are time-consuming and often require the use of instruments to open the child’s eyelids because the child is uncooperative, which is difficult for parents to accept, so early detection is difficult. In early stage of tumor, we can choose local condensation and photocoagulation to preserve better vision. For more advanced retinoblastoma, eye removal was often needed to prevent the cancer cells from spreading further into the brain or the tumor from breaking through the eye and growing outward. Looking at the empty eye socket and thinking that the baby will never be able to see again is often unacceptable to parents. Some parents may choose to forgo treatment because they cannot bear to see their child living without quality of life. The only options for conservative treatment are chemotherapy or local radiotherapy. Children with retinoblastoma are often weak because of tumor invasion, and the side effects of chemotherapy are too much for them to bear. Local chemotherapy has become a new option for retinoblastoma. By injecting anti-tumor drugs directly into the eye, the tumor gradually shrinks and even disappears eventually, or after the tumor shrinks, it is supplemented by local condensation or photocoagulation, so that the child does not have to remove the eye and can even retain part of his or her vision.