Diabetic nephropathy is one of the most common microvascular complications of diabetes mellitus. Diabetic nephropathy stage II generally does not affect the life expectancy if it is actively treated, and the life expectancy is more than a few decades, and even no difference with normal people; if the treatment is untimely, the treatment adherence is poor, and the condition continues to deteriorate, the patient may enter into the uremic stage within 5 years. Diabetic nephropathy stage II is characterized by persistent microalbuminuria, normal or elevated GFR, and clinical asymptomatic. Renal pathology is characterized by thickening of glomerular/tubular basement membrane and widening of the tethered zone. Aggressive treatment of diabetic nephropathy stage II usually does not affect life expectancy. The treatment of diabetic nephropathy is based on diet control, lowering sugar and blood pressure and lipid regulation, and treatment of complications, etc., and nephrotoxic drugs are avoided as much as possible. If the patient is not timely treated, poor treatment compliance, and the condition continues to deteriorate, the patient may enter the uremic stage within 5 years. When the GFR is <15ml/min, or accompanied by uncontrollable heart failure, severe gastrointestinal symptoms, hypertension, etc., dialysis and renal transplantation should be chosen according to the conditions. Patients with diabetic nephropathy stage II should go to the hospital in time and under the guidance of professional physicians for standardized treatment.