The normal value of glutathione/glutathione is 1.15, and the ratio of 0.5 is low. It needs to be analyzed specifically with the values of glutathione aminotransferase (AST) and glutathione alanine aminotransferase (ALT). If the AST value is within 8-40U/L and ALT is within 5-40U/L, the low AST/ALT is not meaningful. It may be caused by the presence of bad habits such as heavy drinking, staying up late, overworking, or the presence of large fat intake in the diet and pregnancy in women, which causes a temporary increase in ALT and thus a low AST/ALT. Usually, no special intervention is needed. Proper rest and good daily habits are sufficient. If the AST or ALT is abnormal, it may be due to disease factors, such as acute viral hepatitis, chronic viral hepatitis, etc. In this case, you need to go to the hospital to improve the relevant examination to clarify the cause of liver damage, and to treat the cause. I. Etiology: 1. Acute viral hepatitis: both AST and ALT are significantly elevated, usually ALT > 300 U/L, AST > 200 U/L, AST/ALT < 1, is an important means of diagnosing acute viral hepatitis; 2. Chronic viral hepatitis: AST/ALT < 1 accompanied by a mild rise in serum transaminases. Second, treatment: 1, antiviral drugs: can follow medical advice to use interferon, tenofovir, sofosbuvir and other drugs antiviral treatment to inhibit viral replication to improve liver function; 2, liver-protective drugs: can follow medical advice to take oral reduced glutathione, glycopyrrolate preparations and other liver-protective drugs to promote physical recovery; 3, other: if liver damage is serious, drug treatment is not effective, if necessary, liver transplantation or artificial liver treatment.